Three trials have shown remarkable benefits of thrombectomy in patients with large ischemic strokes in countries with different medical systems. The benefits of thrombectomy were consistent across age, degree of neurologic deficit, imaging characteristics, time of treatment, and geographic location. Thrombectomy resulted in significantly better functional outcomes than medical care […]
A prospective US cohort study indicated that premature cardiovascular disease (CVD before 60 years) is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVD risk factors. The study included 3,146 participants, who were 18-30 years at baseline (1985-86, […]
A US cohort study suggested that initiation of medications for high blood pressure that stimulate vs inhibit type 2 and 4 angiotensin II receptors may result in a lower risk of incident dementia. The study included 57 773 patients aged 65 years or older with incident high blood pressure from January […]
A UK longitudinal cohort study suggested that the predictive ability of a polygenic risk score (PRS) for coronary artery disease (CAD) was greater in younger individuals and could be used to better identify patients with borderline and intermediate clinical risk who should initiate statin therapy. Polygenic risk for CAD was […]
A US study showed that intensive systolic blood pressure (SBP) lowering increased hs-cTnT (high-sensitivity cardiac troponin T), mediated by reduced kidney filtration; and decreased NT-proBNP (N-terminal pro-B-type natriuretic peptide), mediated by the drop in SBP. The observed changes in hs-cTnT and NT-proBNP levels with intensive SBP lowering were associated with […]
A global study concluded that exposure to extreme hot and cold temperatures was associated with a higher mortality from multiple common cardiovascular diseases (CVD). The study used data of daily counts of specific CVD death from 567 cities in 27 countries across 5 continents in overlapping periods ranging from 1979 […]
A systematic review and meta-analysis of randomized controlled intervention trials of micronutrients on cardiovascular disease (CVD) and clinical events concluded that some but not all micronutrients may be beneficial. The analysis identified a total of 884 randomized controlled intervention trials evaluating 27 types of micronutrients among 883,627 participants (4,895,544 person-years). […]
An interim report of a US randomized trial in patients with stable coronary disease and moderate or severe ischemia concluded that there was no difference in all-cause mortality for an initial invasive strategy compared with an initial conservative strategy, with lower risk of cardiovascular mortality but higher risk of non-cardiovascular […]
An open-label, blinded-endpoint, randomized controlled trial in China suggested that intensive control of systolic blood pressure (SBP) to lower than 120 mm Hg should be avoided to prevent compromising the functional recovery of patients who have received endovascular thrombectomy due to intracranial large-vessel occlusion. The trial enrolled 821 patients (aged […]
A prospective histological cohort study in Japan revealed the association of periodontitis with atrial fibrosis. The study enrolled 76 patients with atrial fibrillation (AF, 55 with nonparoxysmal AF, 25 with mitral valve regurgitation, 18 with left atrial appendages [LAA] thrombus) who were scheduled to undergo LAA excision during cardiac surgery. […]