A cross-sectional, observational study of 2 genotyped cohorts in Australia and UK suggested that sodium was associated with larger hypertensive effects for individuals with higher blood pressure (BP) genetic risk in pathways related to sodium and potassium biology. Both genetic risk and urinary electrolytes independently correlated with BP in the […]
In the prespecified analysis of a randomized, double-blind, placebo-controlled trial, bempedoic acid reduces LDL cholesterol, high-sensitivity C-reactive protein, and risk of cardiovascular events among those with baseline diabetes, prediabetes, or normoglycemia, with or without cardiovascular disease at baseline. Between Dec 22, 2016, and Nov 7, 2022, 13 970 patients who were […]
A Finnish randomized, infancy-onset cohort study indicated that accumulation of risk exposure to BP levels at all life stages contributed to adulthood carotid intima-media thickness (IMT). The study included 534 participants from July 1989 through January 2018 with annual BP (from age 7 months to 20 years), biennial IMT measurements […]
The US 2023 atrial fibrillation (AF) guideline emphasizes a rhythm control strategy and highlight the need for lifestyle and risk factor modification in addition to medical treatment. Key points including: The new proposed classification of AF by 4 stages, recognizes AF as a disease continuum that requires a variety of […]
A longitudinal cohort and mendelian randomization study suggested there was a modest, but significant longitudinal and causal relationship between neuroticism and atrial fibrillation (AF). In 394,834 UK participants (mean age 56.3 years, 45.9% male), AF occurred in 23,509 (6.0%) during a 10-year follow-up. Based on the median summary score from […]
A Spanish longitudinal cohort study suggested that the impact of low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) on subclinical atherosclerosis (SA) progression might be more pronounced in younger participants. SA was quantified as global plaque volume (bilateral carotid and femoral plaque burden) in 3,471 asymptomatic participants (baseline age […]
A UK prospective cohort analysis suggested that both functional (subjective) and structural (objective) measures of social connection were independently associated with all-cause and cardiovascular disease (CVD) mortality. The analysis included 458,146 participants with a median of 12.6 years follow-up, 33,135 (7.2%) deaths, including 5112 (1.1%) CVD deaths. Friends/family visit frequencies < monthly were […]
A multicenter, open-label, randomized crossover trial with blinded endpoint assessment in Europe revealed that 4 weeks of treatment with amlodipine, losartan, or atenolol resulted in differential effects on cerebrovascular reactivity (CVR) in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) but not in patients with symptomatic […]
A US cohort study suggests that high blood pressure variability (BPV) can indicate increased incident dementia risk in older age. The study focused on 820 participants (mean age, 77.0 years; 58.0% females) with data of brain autopsy and midlife to late-life BP. A mean of 28.4 yearly SBP measurements were […]
A double-blind, double-dummy, randomized trial in European countries revealed that among patients with atrial high-rate episodes (AHREs) detected by implantable devices, anticoagulation with edoxaban led to a higher incidence of a composite of death or major bleeding but did not significantly improve efficacy outcomes. A total of 2536 patients 65 […]