To address uncertainties in statin safety profiles, which are often based on observational data susceptible to bias, researchers conducted a definitive meta-analysis of individual participant data from major double-blind, randomized controlled trials. The study first identified all undesirable effects listed in the official Summaries of Product Characteristics (SmPCs) for five […]
Recent US stroke guidelines incorporate significant advances across the care continuum. Mobile Stroke Units (MSUs) are now recommended for their ability to accelerate thrombolysis. For suspected large vessel occlusion, bypassing to an endovascular thrombectomy (EVT)-capable center is endorsed when efficient. Intravenous thrombolysis (IVT) guidelines now include tenecteplase as non-inferior to […]
A systematic review and meta-analysis of 27 observational studies, encompassing over 74,000 participants from 7 countries, indicates that consuming water with higher salinity is associated with increased blood pressure and hypertension risk. The analysis found that higher drinking water salinity was linked to average increases of 3.22 mm Hg in […]
According to a systematic review and meta-analysis encompassing over 22 million participants and spanning from 1966 to 2021, specific mental disorders have been confirmed to be significantly associated with an increased risk of Acute Coronary Syndrome (ACS). The study screened 3,616 initial records from three major databases, ultimately incorporating 25 […]
Long-term and intensive night shift work was associated with a significantly higher risk of cardiovascular–kidney–metabolic (CKM) disease in a large UK Biobank cohort, with the strongest effects seen among individuals who slept six hours or less per night. Among 96,365 participants followed through 2022, those with more than 20 years […]
Depression and anxiety were each associated with a higher risk of major adverse cardiac events, with the greatest risk observed when both conditions co-occurred, and these associations were partly mediated by heightened stress-related neural activity and downstream autonomic and inflammatory dysregulation. In more than 85,000 participants from the Mass General […]
Achieving remission of prediabetes was associated with an approximately 50% lower long-term risk of death from cardiovascular disease (CVD) or hospitalization for heart failure, with benefits persisting for decades in two landmark diabetes prevention cohorts. In post hoc analyses of the US Diabetes Prevention Program Outcomes Study and the Chinese […]
Recent recommendations of the American College of Cardiology/American Heart Association Joint Committee emphasize that adults with congenital heart disease achieve better outcomes when managed at specialized adult congenital heart disease (ACHD) centers with multidisciplinary teams and close involvement of ACHD cardiologists, particularly for patients with moderate or complex anatomy or […]
Intensive blood pressure (BP) control targeting <130/80 mm Hg reduced cardiovascular events and mortality consistently across all baseline diastolic blood pressure (DBP) strata in a post hoc analysis of 33,288 participants from the China Rural Hypertension Control Project, with no evidence that lower DBP diminished benefit. Participants were categorized into […]
In nearly 450,000 adults without known atherosclerotic cardiovascular disease (CVD), elevated high-sensitivity C-reactive protein (hsCRP) independently predicted major adverse CVD events and mortality, outperformed several conventional risk factors, and significantly improved the Systematic COronary Risk Evaluation 2 (SCORE2)-based risk prediction. In this UK Biobank study, participants had a median age […]