Achieving remission of prediabetes was associated with an approximately 50% lower long-term risk of death from cardiovascular disease (CVD) or hospitalization for heart failure, with benefits persisting for decades in two landmark diabetes prevention cohorts. In post hoc analyses of the US Diabetes Prevention Program Outcomes Study and the Chinese […]
In nearly 450,000 adults without known atherosclerotic cardiovascular disease (CVD), elevated high-sensitivity C-reactive protein (hsCRP) independently predicted major adverse CVD events and mortality, outperformed several conventional risk factors, and significantly improved the Systematic COronary Risk Evaluation 2 (SCORE2)-based risk prediction. In this UK Biobank study, participants had a median age […]
In a population-based analysis of 371,032 UK Biobank participants, faster biological aging in males explained a substantial proportion of their higher cardiovascular disease (CVD) risk compared with females, accounting for about 60–68% of the excess risk across major CVD outcomes. Although males and females had similar chronological ages, males consistently […]
A systematic review of 17 randomized trials involving 66,337 adults found that reducing or modifying saturated fat intake offers little or no clinically meaningful benefit over five years for people at low cardiovascular risk, but may lead to important reductions in mortality and major cardiovascular events among those at high […]
Low-dose colchicine reduces myocardial infarction and stroke in people with cardiovascular disease (CVD) without increasing serious adverse events, although it raises the risk of mild gastrointestinal symptoms and shows no clear effect on mortality or revascularization. In an updated Cochrane review of 12 randomized controlled trials including 22,983 participants followed […]
Daily supplementation with n−3 polyunsaturated fatty acids (fish oil) significantly reduced the risk of serious cardiovascular events in patients receiving maintenance hemodialysis. In a double-blind, randomized, placebo-controlled trial across 26 sites in Canada and Australia, 1,228 adults on hemodialysis were assigned to receive either 4 g of fish oil daily […]
A natural experiment study investigated whether exposure to sugar rationing during early life was associated with reduced risk of cardiovascular disease (CVD) in adulthood. Using data from 63,433 UK Biobank participants born between 1951 and 1956, researchers compared individuals exposed to sugar rationing in utero or early childhood with those […]
Data from the Global Burden of Disease (GBD) 2023 study showed that cardiovascular diseases (CVDs) remain the leading cause of death and disability worldwide, with their burden continuing to rise since 1990 due to population growth, aging, and changing exposures to harmful risk factors. The GBD study covered 204 countries […]
A global analysis of over 2 million individuals from 133 cohorts across 39 countries found that five classic risk factors—high blood pressure, hyperlipidemia, underweight/overweight or obesity, diabetes, and smoking—account for about half of the global cardiovascular disease (CVD) burden. Researchers estimated lifetime risks and outcomes up to age 90 based […]
A UK longitudinal associations study revealed that hyperlipidemias and inflammation independently and together raise the risk of serious cardiovascular diseases (CVD). The risk is more closely tied to the actual blood levels of these markers than to the use or not of cholesterol-lowering medication. Data were from 322,922 participants (55.9% […]