A prospective UK cohort study revealed that younger age at diabetes onset was associated with higher risk of subsequent dementia. The study included 10 095 participants (67.3% men; aged 35-55 years in 1985-1988), with a total of 1710 cases of diabetes and 639 cases of dementia recorded over a median follow-up […]
A Canadian population-based cohort study revealed dose-dependent increases in skin cancer risk associated with thiazides in people aged 66 years and older. The study included a total of 302 634 adults aged ≥ 66 years prescribed an antihypertensive medication and 605 268 matched unexposed adults. Increasing thiazide exposure was associated […]
Rare and unusual adverse thrombotic events and thrombocytopenia may be associated with COVID-19 vaccines from AstraZeneca and Johnson & Johnson (J&J), so called vaccine-associated immune thrombotic thrombocytopenia (VITT). VITT resembles autoimmune heparin-induced thrombocytopenia, a well-known prothrombotic disorder caused by platelet-activating antibodies that recognize multimolecular complexes between cationic platelet factor 4 […]
A study in a large, geographically diverse population confirmed that diets with a high glycemic index were associated with an increased risk of cardiovascular disease (CVD) and death. The study included 137,851 participants between the ages of 35 and 70 years living on five continents, with 8780 deaths and 8252 […]
A systematic review and meta-analysis suggests that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may be associated with protective effects for patients with COVID-19. The analysis included 52 studies that evaluated clinical outcomes among 101 949 total patients, of whom 26.0% were receiving ACEIs or ARBs. When adjusted for […]
The European Association of Preventive Cardiology (EAPC) and the ESC Council on Hypertension have proposed that type of exercise can be prescribed according to initial blood pressure (BP) level to optimize lifestyle interventions for the prevention and treatment of high BP. A systematic review of meta-analyses was performed to determine […]
A US prospective cohort study supports that higher consumption of ultra-processed foods is associated with increased risk of cardiovascular disease (CVD) incidence and mortality. The study included 3,003 adults free from CVD with valid dietary data at baseline and followed from 1991 to 2014/2017. Ultra-processed foods were defined according to […]
A prospective study revealed that cardiovascular disease (CVD) risk factors, 10-year atherosclerotic CVD (ASCVD) risk score, and natriuretic peptide concentrations are associated with increased risk of future cancer. Conversely, a heart healthy lifestyle is associated with a lower risk of future cancer. The study included 20,305 participants, mean age 50 […]
A pooled analysis of individual participant data of 4 international cohort studies suggested that fish intake of 2 servings weekly is associated with lower risk of major cardiovascular disease (CVD) and mortality among patients with prior CVD. The analysis involved 191 558 participants with a mean age of 54.1 years, 47.9% […]
Results from 2 prospective cohort studies of US men and women and a meta-analysis of 26 cohort studies found an inverse association between fruit and vegetable intake and mortality up to approximately 5 servings/day.The 2 prospective cohort studies included 66719 women (1984–2014) and 42016 men (1986–2014), and the dose-response meta-analysis […]