An analysis from the FOURIER trial found that among patients with established atherosclerotic cardiovascular disease, lower lipoprotein(a) [Lp(a)] concentrations were associated with a higher prevalence of diabetes at baseline and a greater risk of developing diabetes during follow-up, while showing no increased risk of most other major adverse safety outcomes. […]
Even alcohol consumption commonly considered “moderate” was associated with increased lifetime risks of death and disease, with no evidence of a net protective health effect at low levels of drinking. Researchers estimated alcohol-attributable mortality and morbidity risks in the US by integrating data from national health surveys, U.S. Census population […]
A nationally representative study of 5,370 older US adults found that higher consumption of ultraprocessed foods (UPFs) was associated with significantly increased risks of dementia, cognitive impairment without dementia (CIND), and the combined outcome of CIND or dementia. Researchers analyzed data from the Health and Retirement Study between 2013 and […]
Long-term follow-up of two randomized lifestyle intervention trials found that reducing visceral fat—not simply losing weight—was strongly associated with sustained cardiometabolic health benefits, and every 10% reduction in visceral fat lowered the future risk of type 2 diabetes by 28%. Researchers followed 366 participants from the 18-month CENTRAL and DIRECT-PLUS […]
Recently identified brain rhythm during sleep may play a crucial role in clearing neurotoxic waste and protecting against dementia. Unlike wakefulness, when major neuromodulators such as norepinephrine, acetylcholine, serotonin, and dopamine act relatively independently, sleep synchronizes their activity into coordinated oscillations occurring approximately every 50 seconds. These rhythmic fluctuations are […]