Hyperglycosylation Maybe a Key Driver of Alzheimer’s Disease Progression
A new study identifies brain hyperglycosylation—an excessive buildup of sugar-containing glycans on proteins—as a pathological driver of Alzheimer’s disease (AD), revealing a promising new target for treatment. By integrating spatial metabolomics, lipidomics, glycomics, and advanced isotopic tracing techniques in transgenic AD mouse models and post-mortem human brain samples, researchers found […]