A systematic review and meta‐analysis suggests that influenza, SARS‐CoV‐2, HIV, hepatitis C virus, and herpes zoster are all associated with an increased risk of major cardiovascular events. The analysis included 155 studies, viral infections were consistently linked to higher rates of coronary heart disease (CHD) and stroke. HIV infection was […]
Ongoing peer-reviewed evidence supports the safety and effectiveness of vaccines against Covid-19, respiratory syncytial virus (RSV), and influenza during the 2025–2026 season. In a systematic review of 511 studies out of 17,263 identified references, Covid-19 mRNA vaccines targeting the XBB.1.5 subvariant showed pooled effectiveness against hospitalization of 46% from cohort […]
A placebo-controlled, n-of-1 study suggested that coronary collateralization may lessen the intensity of ischemic chest pain. The study included 51 participants with stable single-vessel coronary artery disease and angina. After discontinuing antianginal medications, participants recorded daily angina using a smartphone app for 14 days before undergoing invasive pressure wire studies […]
Findings of a UK clinical trial support the use of the Mediterranean diet (MD) as a first-line therapy for irritable bowel syndrome (IBS). A total of 139 adults with IBS (mean age 40.4 years; 80% women) from across the UK were randomized to follow either the MD (n = 68) […]
A natural experiment study investigated whether exposure to sugar rationing during early life was associated with reduced risk of cardiovascular disease (CVD) in adulthood. Using data from 63,433 UK Biobank participants born between 1951 and 1956, researchers compared individuals exposed to sugar rationing in utero or early childhood with those […]
A systematic review and network meta-analysis evaluated the efficacy and safety of different exercise modalities for managing knee osteoarthritis, including aerobic, flexibility, mind-body, neuromotor, strengthening, and mixed exercises. A total of 217 randomized controlled trials involving 15,684 participants were analyzed, with outcomes assessed at short-term (4 weeks), mid-term (12 weeks), […]
The British Dietetic Association has developed the first comprehensive evidence-based dietary guidelines for the management of chronic constipation in adults. Four systematic reviews and meta-analyses encompassing 75 randomized controlled trials informed 59 recommendation statements, developed through the GRADE framework and Delphi consensus among a multidisciplinary Guideline Steering Committee. The recommendations […]
The American Association of Clinical Endocrinology (AACE) has released its 2025 Consensus Statement and updated algorithm for the management of adults with dyslipidemia, offering concise visual guidance and tables to support clinical decision-making aimed at reducing atherosclerotic cardiovascular disease (ASCVD) and triglyceride-induced pancreatitis risk. Developed by an international multidisciplinary task […]
A study shows that autism diagnosed earlier versus later in life may reflect different developmental pathways and genetic profiles. In longitudinal data from four birth cohorts, there were two distinct socioemotional and behavioral trajectories tied to age at autism diagnosis. Genetic factors explained about 11% of the variation in when […]