The analysis of genetic and lifestyle factors with cancer incidence in a general-population cohort suggested that genetic cancer risk may be reduced by adopting a healthy lifestyle. An incidence-weighted overall cancer polygenic risk score (CPRS) was constructed based on 20 cancer site-specific polygenic risk scores. Lifestyle was determined according to […]
The International Association for the Study of Pain has proposed a new term, nociplastic pain, to describe a third category of pain that is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of tissues, and neuropathic pain, which is caused by nerve damage. The mechanisms […]
A prospective UK cohort study revealed that younger age at diabetes onset was associated with higher risk of subsequent dementia. The study included 10 095 participants (67.3% men; aged 35-55 years in 1985-1988), with a total of 1710 cases of diabetes and 639 cases of dementia recorded over a median follow-up […]
A Canadian population-based cohort study revealed dose-dependent increases in skin cancer risk associated with thiazides in people aged 66 years and older. The study included a total of 302 634 adults aged ≥ 66 years prescribed an antihypertensive medication and 605 268 matched unexposed adults. Increasing thiazide exposure was associated […]
Rare and unusual adverse thrombotic events and thrombocytopenia may be associated with COVID-19 vaccines from AstraZeneca and Johnson & Johnson (J&J), so called vaccine-associated immune thrombotic thrombocytopenia (VITT). VITT resembles autoimmune heparin-induced thrombocytopenia, a well-known prothrombotic disorder caused by platelet-activating antibodies that recognize multimolecular complexes between cationic platelet factor 4 […]
A study in a large, geographically diverse population confirmed that diets with a high glycemic index were associated with an increased risk of cardiovascular disease (CVD) and death. The study included 137,851 participants between the ages of 35 and 70 years living on five continents, with 8780 deaths and 8252 […]
A systematic review and meta-analysis suggests that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may be associated with protective effects for patients with COVID-19. The analysis included 52 studies that evaluated clinical outcomes among 101 949 total patients, of whom 26.0% were receiving ACEIs or ARBs. When adjusted for […]
A prospective study revealed that cardiovascular disease (CVD) risk factors, 10-year atherosclerotic CVD (ASCVD) risk score, and natriuretic peptide concentrations are associated with increased risk of future cancer. Conversely, a heart healthy lifestyle is associated with a lower risk of future cancer. The study included 20,305 participants, mean age 50 […]
A global study concluded that a diet with a high glycemic index was associated with an increased risk of cardiovascular disease (CVD) and death. The study included 137,851 participants between the ages of 35 and 70 years living on five continents, with a median follow-up of 9.5 years. Country-specific food-frequency […]
A multi-parametric cardiovascular magnetic resonance (CMR) assessment revealed myocardial injury in approximately half of hospitalized COVID-19 patients. A total of 148 hospitalized COVID-19 patients (64 ± 12 years, 70% male, 32% requiring ventilatory support) and troponin elevation discharged from six hospitals in the UK underwent convalescent CMR (including adenosine stress perfusion if indicated) […]