Rare and unusual adverse thrombotic events and thrombocytopenia may be associated with COVID-19 vaccines from AstraZeneca and Johnson & Johnson (J&J), so called vaccine-associated immune thrombotic thrombocytopenia (VITT). VITT resembles autoimmune heparin-induced thrombocytopenia, a well-known prothrombotic disorder caused by platelet-activating antibodies that recognize multimolecular complexes between cationic platelet factor 4 […]
A study in a large, geographically diverse population confirmed that diets with a high glycemic index were associated with an increased risk of cardiovascular disease (CVD) and death. The study included 137,851 participants between the ages of 35 and 70 years living on five continents, with 8780 deaths and 8252 […]
A systematic review and meta-analysis suggests that angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) may be associated with protective effects for patients with COVID-19. The analysis included 52 studies that evaluated clinical outcomes among 101 949 total patients, of whom 26.0% were receiving ACEIs or ARBs. When adjusted for […]
A prospective study revealed that cardiovascular disease (CVD) risk factors, 10-year atherosclerotic CVD (ASCVD) risk score, and natriuretic peptide concentrations are associated with increased risk of future cancer. Conversely, a heart healthy lifestyle is associated with a lower risk of future cancer. The study included 20,305 participants, mean age 50 […]
A global study concluded that a diet with a high glycemic index was associated with an increased risk of cardiovascular disease (CVD) and death. The study included 137,851 participants between the ages of 35 and 70 years living on five continents, with a median follow-up of 9.5 years. Country-specific food-frequency […]
A multi-parametric cardiovascular magnetic resonance (CMR) assessment revealed myocardial injury in approximately half of hospitalized COVID-19 patients. A total of 148 hospitalized COVID-19 patients (64 ± 12 years, 70% male, 32% requiring ventilatory support) and troponin elevation discharged from six hospitals in the UK underwent convalescent CMR (including adenosine stress perfusion if indicated) […]
A study shows that human sleep is synchronized with lunar phases regardless of ethnic and sociocultural background, and of the level of urbanization. The study uses wrist actimetry to show a clear synchronization of nocturnal sleep timing with the lunar cycle in participants living in environments that range from a […]
The 2020-2025 Dietary Guidelines for Americans are out. For the first time the Guidelines provide recommendations by life stage, from birth through older adulthood, while focusing on dietary patterns and recognizing that more than half of adults have one or more diet-related chronic diseases. The guidelines: for about the first […]
A harmonized meta-analysis concluded that longer sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30–40min of moderate-to-vigorous-intensity physical activity (MVPA) per day attenuate the association between sedentary time and risk of death. The analysis included 44370 middle-aged and older men and women […]
A US randomized clinical trial revealed that a low-fat plant-based diet is effective in reducing body weight and increasing insulin sensitivity and postprandial metabolism. A total of 244 participants with body mass index of 28 to 40 (87% female, 48% White, mean age 54.4 years) were randomized in a 1:1 […]