A US cohort study found that the neutrophil-to-lymphocyte ratio (NLR) was prospectively associated with all-cause mortality and cardiovascular disease (CVD). A Duffy antigen variant locus, a common genetic variant of African origin, was associated with a lower baseline NLR and modified the associations. The study included a population-based longitudinal cohort […]
A study in US adults concluded that a healthy lifestyle could substantially reduce premature mortality and prolong life expectancy. The study included 123,329 adults and defined 5 low-risk lifestyle factors as never smoking, body mass index of 18.5 to 24.9 kg/m2, ≥30 min/d of moderate to vigorous physical activity, moderate […]
A prospective Swedish study suggests that nuts consumption or factors associated with it may play a role in reducing the risk of atrial fibrillation. The study included 61 364 Swedish adults followed up for 17 years. There was an inverse association between nuts consumption and incident atrial fibrillation, and remained […]
A Canadian cohort study suggested that congenital heart defects in offspring may be an early marker of predisposition to cardiovascular disease (CVD). The study included 1 084 251 women who had delivered infants between 1989 and 2013, with follow-up extending up to 25 years past pregnancy. Women whose infants had […]
A multi-center registry in the US revealed that myocarditis associated with immune checkpoint inhibitors (ICI) may occur early, has a malignant course and may respond to higher doses of steroids. The initial 35 cases were diagnosed between November 2013 and July 2017, with an incidence of 1.9% and median onset […]
Growing body of evidence supports that increasing adiposity has a detrimental association with cardiovascular disease (CVD) and longevity. The association of body mass index (BMI) with CVD appeared more susceptible to confounding due to pre-existing comorbidities. Associations of waist circumference, waist-to-hip ratio, waist-to-height ratio, and percentage body fat mass with […]
A randomized clinical study of specifically designed isoenergetic diets, together with fecal shotgun metagenomics, showed that a select group of short-chain fatty acid (SCFA)-producing strains of the gut microbiota was promoted by dietary fibers, and correlated with improved blood-glucose regulation in type 2 diabetes mellitus (T2D). The improvement in hemoglobin […]
“Time is brain,” the time-focused mantra has been extended in acute stroke care. Findings of 2 recent trials—showing that a mechanical thrombectomy treatment window of 16 to even 24 hours can still benefit imaging-selected patient—have been adopted into the new American Heart Association/American Stroke Association guidelines. Strokes develop differently; some […]
A randomized study concluded that catheter ablation for atrial fibrillation (AF) in patients with heart failure (HF) was associated with a significantly lower rate of death from any cause or hospitalization for worsening HF than was medical therapy. The study randomly assigned HF patients with symptomatic paroxysmal or persistent AF […]
A retrospective study of a community-based cohort in the US revealed that resting heart rate (HR) and change in heart rate over time (ΔHR) are associated with mortality and nonfatal outcomes of incident heart failure, myocardial infarction, and stroke. The study included 15 680 white and African American participants (55.2% women, […]