An ongoing study in the UK revealed that systolic blood pressure (SBP) ≥130 mmHg at age 50 is associated with increased risk of dementia, independent of cardiovascular disease (CVD). Systolic and diastolic blood pressure were measured on 8639 persons (32.5% women) in 1985, 1991, 1997, and 2003. Incidence of dementia (n […]
A long term cohort study in the US revealed that obesity remains a risk factor for cardiovascular disease (CVD), even when metabolic health is maintained during long periods of time. A large proportion of metabolically healthy women converted to an unhealthy phenotype over time across all BMI categories, which is […]
A Spanish study identified that cardiomyopathy-associated genes titin truncating variants (TTNtv) represent a prevalent genetic predisposition for alcoholic cardiomyopathy (ACM), and are also associated with a worse left ventricular ejection fraction in dilated cardiomyopathy (DCM) patients who consume alcohol above recommended levels. The study included 141 ACM cases, 716 DCM […]
A prospective cohort study in the US revealed that greater depressive symptoms were associated with worse episodic memory, smaller cerebral volume, and silent infarcts. The study included 1,111 stroke-free older adults with an average age of 71 between 2003 and 2008, 52% were Caribbean Hispanic. 22% of participants had greater […]
A US cohort study found that the neutrophil-to-lymphocyte ratio (NLR) was prospectively associated with all-cause mortality and cardiovascular disease (CVD). A Duffy antigen variant locus, a common genetic variant of African origin, was associated with a lower baseline NLR and modified the associations. The study included a population-based longitudinal cohort […]
A study in US adults concluded that a healthy lifestyle could substantially reduce premature mortality and prolong life expectancy. The study included 123,329 adults and defined 5 low-risk lifestyle factors as never smoking, body mass index of 18.5 to 24.9 kg/m2, ≥30 min/d of moderate to vigorous physical activity, moderate […]
A prospective Swedish study suggests that nuts consumption or factors associated with it may play a role in reducing the risk of atrial fibrillation. The study included 61 364 Swedish adults followed up for 17 years. There was an inverse association between nuts consumption and incident atrial fibrillation, and remained […]
A Canadian cohort study suggested that congenital heart defects in offspring may be an early marker of predisposition to cardiovascular disease (CVD). The study included 1 084 251 women who had delivered infants between 1989 and 2013, with follow-up extending up to 25 years past pregnancy. Women whose infants had […]
A multi-center registry in the US revealed that myocarditis associated with immune checkpoint inhibitors (ICI) may occur early, has a malignant course and may respond to higher doses of steroids. The initial 35 cases were diagnosed between November 2013 and July 2017, with an incidence of 1.9% and median onset […]
Growing body of evidence supports that increasing adiposity has a detrimental association with cardiovascular disease (CVD) and longevity. The association of body mass index (BMI) with CVD appeared more susceptible to confounding due to pre-existing comorbidities. Associations of waist circumference, waist-to-hip ratio, waist-to-height ratio, and percentage body fat mass with […]