A meta-analysis and a meta-regression of randomized clinical trials suggested that more intensive differential blood pressure (BP)–lowering may be beneficial for prevention of recurrent stroke and major cardiovascular events. The analysis included 10 randomized clinical trials comprising 40 710 patients (women 34%; mean age 65 years) with stroke or transient ischemic […]
The US Preventive Services Task Force recommends against initiating low-dose aspirin use for the primary prevention of cardiovascular disease (CVD) in adults 60 years or older. The decision to initiate low-dose aspirin use for the primary prevention of CVD in adults aged 40 to 59 years who have a 10% […]
A Canadian study demonstrated that preactivating lower body muscle (PREACT) and leg crossing with muscle tensing (TENSE) after standing attenuates symptoms and blood pressure (BP) drop of initial orthostatic hypotension (IOH) upon standing. The study included 24 female IOH participants (mean ± SD: 32 ± 8 years) completed 3 sit-to-stand […]
A multi-domain lifestyle intervention among older Finnish adults was effective in preventing cerebrovascular events and total cardiovascular disease (CVD) events among those with a history of CVD. A total of 1259 individuals aged 60–77 years with elevated risk for dementia were randomized (1:1) to a 2-year multi-domain intervention with diet, […]
A US prospective cohort study suggests that most gout cases could potentially be prevented by achieving and maintaining a normal weight, eating a DASH-style diet, and avoiding alcohol consumption and diuretic use. Men with obesity may not benefit from other modifications unless weight loss is addressed. The study included 44 654 […]
The secondary analysis of a US randomized, double-blind, placebo-controlled clinical trial suggested that vitamin D3 apparently reduced the risk of developing advanced cancer among adults who have normal but not elevated body mass index (BMI). The trial included 25 871 randomized participants (51% female; mean age, 67.1 years), 1617 were diagnosed […]
A randomized, controlled, double-blind trial showed that 0.5 mg of colchicine once daily significantly reduced cardiovascular disease (CVD) events in patients with chronic coronary disease in Australia and the Netherlands. The trial included 5522 patients, >80% male, 35 to 82 years of age (2762 assigned to colchicine and 2760 to […]
An UK multicenter, randomized, double-blind, placebo-controlled trial suggests that aspirin and omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) might have chemopreventive effect on colorectal adenomas. Between Nov 11, 2011, and June 10, 2016, 709 patients aged 55–73 years who were identified during colonoscopy as being at high risk were randomly […]