Higher physical activity in midlife and late life—but not early adulthood—is associated with a significantly lower risk of both all-cause and Alzheimer disease dementia. In this prospective analysis from the US Framingham Heart Study Offspring cohort, 1526 early-adult, 1943 midlife, and 885 late-life participants were followed for up to 37 […]
Higher physical activity may slow cognitive and functional decline in older adults at risk for Alzheimer’s disease (AD) by reducing tau accumulation rather than amyloid burden. In a study of cognitively unimpaired older adults with pedometer-measured step counts, greater physical activity was linked to slower decline among those with elevated […]
Two recent studies highlight the importance of physical activity volume and intensity in reducing cardiovascular disease (CVD) risk and improving longevity. The first study analyzed data from over 24,000 middle-aged and older non-exercisers in the UK Biobank, examining the effects of incidental physical activity (IPA)—unstructured daily movement outside formal exercise—on […]
A US cohort study suggested that physical activity (PA) appears to reduce cardiovascular disease (CVD) risk in part by acting through the brain’s stress-related activity. The study included a total of 50,359 adults (median age 60 years; 40.1% male). Stress-related neural activity was measured as the ratio of resting amygdalar-to-cortical […]
The analysis of a UK cohort study suggests that a weekend warrior pattern of physical activity was associated with similarly lower risks of cardiovascular diseases (CVD) to regular activity. A total of 89 573 individuals (mean age, 62 years; 56% women) who underwent accelerometry were included. When stratified at the threshold […]
A US cohort study suggested that more active time, especially at moderate intensities, and less sedentary time, particularly in longer bouts, may reduce the risk of stroke. The study included 7607 participants (mean age 63.4 years; 54.5% female, 31.6% Black, and 68.4% White), including 54.7% of them resided in the […]
A Spanish observational study suggests that, although physical activity (PA) mitigates partly the detrimental effects of overweight/obesity on the risk of cardiovascular diseases (CVD), excess body weight per se is associated with a remarkable increase in the prevalence of major risk factors. The data from 527 662 participants [32% female; mean […]
A harmonized meta-analysis concluded that longer sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30–40min of moderate-to-vigorous-intensity physical activity (MVPA) per day attenuate the association between sedentary time and risk of death. The analysis included 44370 middle-aged and older men and women […]
A prospective US cohort study showed that replacement of 30 minutes/day of sitting with light physical activity (LPA) or moderate to vigorous physical activity (MVPA) was associated with lower mortality riskamong less active adults. The study included 37,924 men and 54,617 women, of which 14,415 men and 13,358 women died […]
A US prospective observational study showed that high levels of physical activity are associated with prevalent coronary artery calcification (CAC) but are not associated with increased all-cause or cardiovascular disease (CVD) mortality after a decade of follow-up, even in the presence of clinically significant CAC levels. The study included 21 […]