A prospective cohort study suggests that personal exposure to brighter nights and darker days causes circadian disruption with poor health outcomes and increased mortality risk. Avoiding night light and seeking daylight may promote optimal health and longevity. From 2013 to 2016, 88,905 UK Biobank participants (mean age 62.4 years, 56.9% […]
A US prospective cohort study demonstrated that replacement of animal fat with an equivalent amount of plant fat, particularly fat from grains or vegetable oils, was associated with a lower mortality. The study enrolled 407 531 men and women (56.9% male; mean age 61.2 years) from 1995 to 1996 and followed […]
An ongoing UK national prospective program shows remission of type 2 diabetes (T2D) outside of research settings, through at-scale service delivery. Between Sept 1, 2020, and Dec 31, 2022, 7540 people (aged 18–65 years diagnosed with T2D within the last 6 years) were referred, 1740 started total diet replacement (TDR) […]
A US prospective study indicates that urinary metal levels are associated with increased mortality and cardiovascular disease (CVD) risk. The study included a racially diverse population of 6599 participants (mean age, 62.1 years; 53% female) with urinary metals available at baseline (2000 to 2001) and followed through December 2019. During […]
A multilipid score (MLS), reflecting the effects of replacing saturated fat with unsaturated fat on 45 lipid metabolite concentrations, was associated with significantly lower risk of cardiovascular diseases (CVD) and type 2 diabetes (T2D). The MLS was based on lipidomics data from a randomized controlled dietary intervention trial, replacing specific […]
A prospective UK population-based cohort study suggests that higher adherence to the EAT-Lancet diet is associated with lower risks of incident depression, anxiety and their co-occurrence. The study included 180,446 participants (mean age 56.2, male 46.45%) with 11.62 years of follow-up. The diet largely consists of vegetables, fruits, whole grains, […]
A US cohort study concludes that there is no mortality benefit of multivitamin use. The study included 390 124 participants (median age, 61.5 years; 55.4% male) without major chronic diseases from 3 prospective cohort studies. 40.9% of participants were never smokers, and 40.3% were college educated. Among daily multivitamin users, 49.3% […]
A cross-sectional study suggested that higher dietary sodium intake may be associated with a higher risk of atopic dermatitis (AD) diagnosis, active AD, and increasing AD severity. There were 215 832 participants (mean age, 56.52 years; 54.3% female) in the UK analytic cohort with 5% of AD patients. Mean (SD) estimated […]
A US prospective population based cohort study suggested that higher ultra-processed food intake was associated with slightly increased all-cause mortality. The associations were mainly driven by meat/poultry/seafood based ready-to-eat products, sugar and artificially sweetened beverages, dairy based desserts, and ultra-processed breakfast foods. The study included 74 563 women (1984-2018) and 39 501 […]
The US Women’s Health Initiative (WHI) clinical trial results do not support hormone therapy with oral conjugated equine estrogens plus medroxyprogesterone acetate for postmenopausal women or conjugated equine estrogens alone for those with prior hysterectomy to prevent cardiovascular disease, dementia, or other chronic diseases. However, hormone therapy is effective for […]