Higher sodium and lower potassium intakes, as measured in multiple 24-hour urine samples, were associated in a dose–response manner with a higher cardiovascular risk in a pooled random-effects meta-analysis of individual-participant data from six prospective cohorts of generally healthy adults in the US. The analysis included 10,709 participants, mean age […]
Pooled analysis of 2 US prospective cohort studies of patients with stable coronary heart disease (CHD) suggested that myocardial ischemia with mental stress, compared with no ischemia with mental stress, was significantly associated with an increased risk of cardiovascular (CV) death or nonfatal myocardial infarction (MI). The analysis included 918 […]
A Danish cohort study showed that the diagnostic value of a coronary artery calcium (CAC) score was age dependent, with smaller added diagnostic value for younger patients. The cohort included 23 759 symptomatic adult patients who underwent computed tomography angiography between January 2008 and December 2017; median age 58, 55% […]
A German longitudinal study suggested that the association between systolic blood pressure (SBP) and all-cause mortality in older adults may be modified by frailty, with a tendency toward lower risk among those with SBP≥130 mm Hg in frail older adults. The study included 1170 participants (median age 73.9 years, 41.6% […]
A longitudinal cohort study in Italy suggested that non-dipping and reverse dipping blood pressure (BP) patterns are associated with an increased prevalence of cardiac autonomic neuropathy and reduced survival. The study recruited 349 diabetic patients (52% women, age 57.1±11.9 y, BMI 29.4±5.9 kg/m2, HbA1c 8.6±2.1%, 284 with type 2 diabetes) […]
A pooled US cohorts study suggests that maintaining an optimal level of low-density lipoprotein cholesterol (LDL-C) throughout young adulthood and middle age can minimize the lifetime risk for atherosclerotic cardiovascular disease (CVD). The study included data of 18 288 participants (mean age 56.4, 56.4% women) collected from 1971 to 2017 from […]
A prospective observational study indicated that a healthy sleep pattern was associated with lower risks of atrial fibrillation/flutter (AF) and bradyarrhythmia, independent of traditional risk factors, and the association of the healthy sleep pattern with the risk of AF was stronger among those with a lower genetic risk of AF. […]
A Chinese multicenter, randomized, controlled trial concluded that intensive treatment with a systolic blood-pressure (SBP) target of 110 to less than 130 mm Hg resulted in a lower incidence of cardiovascular events than standard treatment with a target of 130 to less than 150 mm Hg. Of the 8511 hypertensive […]
A double-blind, randomized trial revealed that empagliflozin reduced the combined risk of cardiovascular death or hospitalization for heart failure (HF) in patients with HF and a preserved ejection fraction (HFpEF), regardless of the presence or absence of diabetes. The trial included 5988 patients (average 72 years, about 45% women, and […]
A community-based cohort study in Germany suggested that the composition of the gut microbiome might explain the cross-sectional association of habitual flavonoid and flavonoid-rich food intake with blood pressure (BP). The study included 904 participants, and 16S ribosomal RNA was sequenced for the gut microbiome composition. Higher total flavonoid intakes […]