An international randomized trial revealed that an initial invasive approach compared to optimal medical therapy (OMT) in stable ischemic heart disease (SIHD) patients with moderate-severe ischemia did not reduce risk of cardiovascular disease (CVD) end points at a median of 3.3 years. The trial enrolled 5179 SIHD patients with moderate-severe ischemia […]
A randomized, double-blind trial in Canada concluded that among patients with a recent myocardial infarction (MI), colchicine at a dose of 0.5 mg daily led to a significantly lower risk of ischemic cardiovascular events than placebo.A total of 4745 patients within 30 days after a MI were randomly assigned to […]
A meta-analysis of individual participant data from eligible observational studies suggested that use of any antihypertensive medications (AHM) with efficacy to lower blood pressure (BP) might reduce the risk for dementia among people with high BP. However, no evidence was found that a specific AHM drug class was more effective […]
A Spanish multicenter, controlled, prospective endpoint trial suggested that routinely taking blood pressure (BP)-lowering medications at bedtime, as opposed to upon waking, results in improved ambulatory BP (ABP) control and decreased occurrence of major cardiovascular disease (CVD) events. A total of 19 084 hypertensive patients (60.5 ± 13.7 years of age, 8470 women) […]
A systematic review and meta-analysis suggested that global prevalence of hypertension in children is becoming more common. The analysis included 47 studies of children ages 6 to 19, from 1994 to 2018 with at least 3 separate blood pressure measurements. Standardized definitions of hypertension was based on the fourth report […]
A French open-label, randomized, controlled trial showed that among patients with coma who had been resuscitated from cardiac arrest with nonshockable rhythm (asystole or pulseless electrical activity), the use of moderate therapeutic hypothermia at 33°C led to a higher percentage of patients who survived with a favorable neurologic outcome at […]
A meta-analysis and systematic review suggested that optimism is associated with a lower risk of events of cardiovascular diseases (CVD) and all-cause mortality. The analysis included 15 studies of 229 391 participants, in which 10 studies reported data on CVD events (including CVD mortality, nonfatal myocardial infarction, stroke, and/or new-onset angina) […]
A longitudinal population-based cohort study showed that higher 24-hour and nighttime blood pressure (BP) measurements were significantly associated with greater risks of death and a composite cardiovascular (CV) outcome. The study included 11 135 adults from Europe, Asia, and South America (median age, 54.7 years, 49.3% women) with baseline observations collected […]
A US phase 2, multicenter, randomized controlled trial revealed that 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. From May, 2007, to Feb, 2010, the trial randomly assigned 218 participants (21–50 years, BMI 22·0–27·9 kg/m 2) to a 25% calorie restriction diet […]
A meta-analysis of recent randomized controlled trials and systematic reviews concluded that reduced salt intake, omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) use, and folate supplementation could reduce risk for some cardiovascular diseases (CVD). Combined calcium plus vitamin D might increase risk for stroke. The analysis selected 9 systematic reviews and […]