An international, investigator-initiated, parallel-group, open, blinded-outcome-assessment trial concluded that early rhythm-control therapy was associated with a lower risk of cardiovascular (CV) outcomes than usual care among patients with early atrial fibrillation (AF) and CV conditions. A total of 2789 patients who had early AF (diagnosed ≤1 year before enrollment, median […]
A randomized, controlled, double-blind trial showed that 0.5 mg of colchicine once daily significantly reduced cardiovascular disease (CVD) events in patients with chronic coronary disease in Australia and the Netherlands. The trial included 5522 patients, >80% male, 35 to 82 years of age (2762 assigned to colchicine and 2760 to […]
A meta-analysis suggested that long naps (more than 60 mins) were associated with a 30% greater risk of all-cause death and 34% higher likelihood of cardiovascular disease (CVD) compared to no napping. When night-time sleep was considered, long naps were linked with a higher risk of death only in those […]
A state-of-the-art review for saturated fats and health challenges current guideline recommendation to limit dietary saturated fatty acid (SFA) intake. Food sources of SFAs contain different proportions of various fatty acids in addition to other nutrients that can substantially influence their observed physiological and biologic effects. Most recent meta-analyses of […]
A multicenter, controlled, prospective endpoint trial confirmed that routinely taking blood pressure (BP)-lowering medications at bedtime, as opposed to upon waking, resulted in improved ambulatory BP control (significantly enhanced decrease in asleep BP and increased sleep-time relative BP decline, i.e. BP dipping) and markedly reduced major cardiovascular disease (CVD) events. […]
An analysis with critically reviewing the clinical outcomes of randomized controlled trials (RCTs) of cholesterol reduction challenges the current approach to cardiovascular disease (CVD) prevention through targeted reductions of low density lipoprotein cholesterol (LDL-C). Drug treatment to reduce LDL-C to target levels (30% and 50% or more reduction for individuals […]
A US prospective observational cohort study revealed that higher plant protein intake was associated with reductions in risk of overall and cardiovascular disease (CVD) mortality. The study included 237 036 men (57%, median ages 62.2) and 179 068 women (median age 62.0). Based on 6 009 748 person-years of observation, 77 614 deaths (18.7%; 49 297 […]
A global analysis of pooled population-based studies showed the global repositioning of lipid-related risk over the past nearly four decades, with non-optimal cholesterol shifting from high-income countries in northwestern Europe, north America and Australasia to countries in east and southeast Asia and Oceania. The analysis included 1,127 population-based studies that measured […]
A US study of 3 prospective cohorts suggests that greater adherence to various healthy eating patterns was consistently associated with lower risk of cardiovascular disease (CVD). The final study sample included 74 930 women in the 1st cohort (mean baseline age, 50.2 years), 90 864 women in the 2nd cohort (mean baseline […]
A US cohort study revealed that beginning with a systolic blood pressure (SBP) level of 90 mm Hg, there was a stepwise increase in the prevalence of traditional atherosclerotic cardiovascular disease (ASCVD) risk factors, coronary artery calcium, and the risk of ASCVD. The study included 1457 participants free of ASCVD […]