A US phase 2, multicenter, randomized controlled trial revealed that 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. From May, 2007, to Feb, 2010, the trial randomly assigned 218 participants (21–50 years, BMI 22·0–27·9 kg/m 2) to a 25% calorie restriction diet […]
A meta-analysis of recent randomized controlled trials and systematic reviews concluded that reduced salt intake, omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) use, and folate supplementation could reduce risk for some cardiovascular diseases (CVD). Combined calcium plus vitamin D might increase risk for stroke. The analysis selected 9 systematic reviews and […]
A longer period of follow up revealed that there was no evidence of a legacy effect or a mortality benefit with intensive glucose control, although participants with type 2 diabetes who had been randomly assigned to intensive glucose control for 5.6 years had a lower risk of cardiovascular events than […]
A UK prospective cohort study suggested that habitual use of glucosamine supplement to relieve osteoarthritis pain might also be related to lower risks of cardiovascular diseases (CVD) events. The study enrolled 466 039 participants from 2006 to 2010. During a median follow-up of 7 years, there were 10 204 incident CVD events, […]
A longitudinal analysis in Australia revealed that sitting is associated with all-cause and cardiovascular disease (CVD) mortality risk among sedentary adults; moderate-to-vigorous physical activity (MVPA) doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations. During an 8.9-year (median) follow-up, a total of 8,689 deaths (1,644 due […]
A US prospective cohort study revealed that skipping breakfast was associated with a significantly increased risk of mortality from cardiovascular disease (CVD). The study included a nationally representative sample of 6,550 adults (mean age 53.2 years; 48.0% male) from 1988 to 1994, with 17 to 23 years of follow-up. In […]
An analysis of pooled individual participant data collected between March 25, 1985, and August 31, 2016 revealed that higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident cardiovascular disease (CVD) and all-cause mortality in a dose-response manner. The analysis included 29 615 participants (mean age […]
A Mendelian randomization study revealed that genetically predicted endogenous testosterone is positively linked to cardiovascular disease (CVD), including thromboembolism, heart failure (HF), and myocardial infarction (MI) in men. The study identified genetic predictors of endogenous testosterone from a genome wide association study of serum testosterone conducted in 3225 men of […]
A new US National Academies report updated Dietary Reference Intakes for potassium (Adequate Intake [AI] 3400 mg for man and 2600 mg for most women per day) and sodium (AI 1500 mg/day, and Chronic Risk Reduction Intake 2300 mg/day) in healthy adults. There was insufficient evidence of risk of excess […]
A US prospective analysis revealed that higher consumption of nuts, especially tree nuts, is associated with lower cardiovascular disease (CVD) incidence and mortality in patients with diabetes. The analysis included 16,217 men (1986-2014) and women (1980-2014) with diabetes at baseline or diagnosed during follow-up. During 223,682 and 254,923 person-years of […]