A randomized, double-blind, placebo-controlled trial in chronic kidney disease (CKD) and type 2 diabetes (T2D) concluded that treatment with finerenone reduced risks of CKD progression and cardiovascular (CV) events. Between September 2015 and June 2018, 5734 patients with CKD and T2D were randomly assigned in a 1:1 ratio to receive […]
A contemporary primary prevention cohort study and a systematic review and meta-analysis showed that older people with elevated LDL cholesterol had higher absolute risk of atherosclerotic cardiovascular disease (CVD), and lipid lowering was as effective in reducing cardiovascular events as it was in younger ones. The cohort study included 13 779 […]
A prospective US study suggests that dietary patterns with a higher proinflammatory potential were associated with higher risk of cardiovascular disease (CVD). The study included 166,234 women and 43,911 men from 3 cohorts, with 5,291,518 person-years of follow-up. The inflammatory potential of diet was evaluated using a food-based empirical dietary […]
A prospective study suggests that incident cardiovascular disease (CVD) event risk depends on the time course of cumulative prior exposure to low-density lipoprotein cholesterol (LDL-C), the younger the age of exposure accumulation, the greater risk increase. The study included 4,958 asymptomatic adults age 18 to 30 years enrolled from 1985 […]
Two studies suggest that reproductive life span and adverse pregnancy outcomes are sex-specific risk factors for atherosclerotic cardiovascular disease (CVD) in women. One study included 307 855 women from 12 studies. Overall, the mean ages at menarche, menopause, and reproductive life span were 13.0, 50.2, and 37.2 years, respectively. Pooled analyses […]
The American Heart Association just issued a scientific statement for drug-induced arrhythmias. Drugs from many therapeutic classes may cause or ex-acerbate a variety of arrhythmias. Awareness of drugs that may cause arrhythmias and specific arrhythmias that may be drug induced is important. Numerus drugs can prolong the QT interval and […]
An international, investigator-initiated, parallel-group, open, blinded-outcome-assessment trial concluded that early rhythm-control therapy was associated with a lower risk of cardiovascular (CV) outcomes than usual care among patients with early atrial fibrillation (AF) and CV conditions. A total of 2789 patients who had early AF (diagnosed ≤1 year before enrollment, median […]
A randomized, controlled, double-blind trial showed that 0.5 mg of colchicine once daily significantly reduced cardiovascular disease (CVD) events in patients with chronic coronary disease in Australia and the Netherlands. The trial included 5522 patients, >80% male, 35 to 82 years of age (2762 assigned to colchicine and 2760 to […]
A meta-analysis suggested that long naps (more than 60 mins) were associated with a 30% greater risk of all-cause death and 34% higher likelihood of cardiovascular disease (CVD) compared to no napping. When night-time sleep was considered, long naps were linked with a higher risk of death only in those […]
A state-of-the-art review for saturated fats and health challenges current guideline recommendation to limit dietary saturated fatty acid (SFA) intake. Food sources of SFAs contain different proportions of various fatty acids in addition to other nutrients that can substantially influence their observed physiological and biologic effects. Most recent meta-analyses of […]