A collaborative analysis of 3 multinational trials suggested that inflammatory risk was a stronger predictor of cardiovascular disease (CVD) events, CVD death, and all-cause death than residual cholesterol risk in statin users. The analysis included 31245 statin users with/or at high risk of atherosclerotic disease. The observed ranges for baseline […]
A French prospective cohort study concluded that better cardiovascular health (CVH) and the maintenance or improvement of CVH were associated with a lower risk of cancer. The study population included 13,933 participants (mainly Caucasian, mean age 45.3 years, 24% women). After a median follow-up of 24.8 years (19.4-24.9 years), 2,010 […]
A US cross sectional and observational cohort study indicated that sleep irregularity was associated with several markers of subclinical atherosclerosis. The study included 2032 participants (mean age, 68.6±9.2 years; White 37.9%, Chinese 11.1%, Black 27.6%, Hispanic 23.4%) underwent assessments of coronary artery calcium, carotid plaque presence, carotid intima‐media thickness, and the […]
A prospective UK cohort study suggested that higher free sugar intake was associated with higher cardiovascular disease (CVD) incidence and higher triglyceride concentrations within all lipoproteins. Higher fiber intake and replacement of refined grain starch and free sugars with wholegrain starch and non-free sugars, respectively, may be protective for incident […]
Three trials have shown remarkable benefits of thrombectomy in patients with large ischemic strokes in countries with different medical systems. The benefits of thrombectomy were consistent across age, degree of neurologic deficit, imaging characteristics, time of treatment, and geographic location. Thrombectomy resulted in significantly better functional outcomes than medical care […]
A Swedish population-wide longitudinal cohort study suggested that β-blockers were associated with reductions in violence. The study included 1,400,766 individuals aged 15 years or older (50 years and over 86.8%, women 52.2%) who had collected β-blocker prescriptions and followed them for 8 years between 2006 and 2013. 6.9% of the […]
A prospective US cohort study indicated that premature cardiovascular disease (CVD before 60 years) is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVD risk factors. The study included 3,146 participants, who were 18-30 years at baseline (1985-86, […]
A comprehensive meta-analysis concluded that cognitive behavior therapy (CBT) is effective for depression across different formats, ages, target groups, and settings, and as effective as pharmacotherapies at the short term, but more effective at the longer term. The analysis included 409 trials (518 comparisons) with 52,702 patients. CBT had moderate […]
A US cohort study suggested that initiation of medications for high blood pressure that stimulate vs inhibit type 2 and 4 angiotensin II receptors may result in a lower risk of incident dementia. The study included 57 773 patients aged 65 years or older with incident high blood pressure from January […]
A prospective US cohort study with up to 36 years of follow-up concluded that greater adherence to several healthy eating patterns was associated with a lower risk of total and cause-specific mortality. The study included 75 230 women (1984-2020, mean baseline age, 50.2 years) and 44 085 men (1986-2020, mean […]