A US randomized, controlled clinical trial revealed that a dietary change with increased vegetable, fruit, and grain intake reduced the risk of death from breast cancer in postmenopausal women. A total of 48,835 postmenopausal women, aged 50-79 years, with no previous breast cancer and dietary fat intake ≥32% of total […]
A genome-wide study of bipolar disorder (BD) revealed an extensive polygenic genetic architecture of the disease, implicate brain calcium channels and neurotransmitter function in BD etiology, and confirmed that BD is part of a spectrum of highly correlated psychiatric and mood disorders. The study included 20,352 cases and 31,358 controls […]
The US FDA approved tafamidis meglumine (Vyndaqel) and tafamidis (Vyndamax) for the treatment of wild-type or hereditary transthyretin amyloid (ATTR) cardiomyopathy based on a trial that showed a significant reduction in mortality, cardiovascular hospitalizations, and in decline in functional capacity and quality of life. The multicenter, international, double-blind, placebo-controlled, phase […]
The Food and Drug Administration (FDA) is requiring a Boxed Warning, the most prominent warning, to be added to certain common prescription insomnia medicines because of sleep behaviors, including sleepwalking, sleep driving, and engaging in other activities while not fully awake. These complex sleep behaviors have also resulted in deaths. […]
A longitudinal analysis in Australia revealed that sitting is associated with all-cause and cardiovascular disease (CVD) mortality risk among sedentary adults; moderate-to-vigorous physical activity (MVPA) doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations. During an 8.9-year (median) follow-up, a total of 8,689 deaths (1,644 due […]
A US prospective cohort study revealed that skipping breakfast was associated with a significantly increased risk of mortality from cardiovascular disease (CVD). The study included a nationally representative sample of 6,550 adults (mean age 53.2 years; 48.0% male) from 1988 to 1994, with 17 to 23 years of follow-up. In […]
A systematic analysis for the Global Burden of Disease Study 2017 found that suboptimal diet is responsible for more deaths than any other risks and that improvement of diet could potentially prevent one in every five deaths globally. By use of a comparative risk assessment approach and disease-specific population attributable […]
A Chinese genetic epidemiological analyses revealed that alcohol intake uniformly increases blood pressure (BP) and stroke, indicating that the apparently protective effects of moderate alcohol intake against stroke suggested by conventional epidemiological analyses are largely non-causal. The study enrolled 512 715 adults between June 25, 2004, and July 15, 2008, from […]
A prospective US cohort study showed that replacement of 30 minutes/day of sitting with light physical activity (LPA) or moderate to vigorous physical activity (MVPA) was associated with lower mortality riskamong less active adults. The study included 37,924 men and 54,617 women, of which 14,415 men and 13,358 women died […]
An analysis of pooled individual participant data collected between March 25, 1985, and August 31, 2016 revealed that higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident cardiovascular disease (CVD) and all-cause mortality in a dose-response manner. The analysis included 29 615 participants (mean age […]