A systematic review and meta-analysis suggests that the absolute benefits of statins are modest and may not be strongly mediated through the degree of low-density lipoprotein cholesterol (LDL-C) reduction. The analysis included 21 randomized clinical trials that examined the effectiveness of statins in reducing total mortality and cardiovascular outcomes with […]
A substudy of the randomized clinical trial compared intensive vs standard systolic blood pressure (SBP) control revealed that the intensive BP treatment was associated with increased, rather than decreased, cerebral perfusion. The substudy included 547 participants (mean age 67.5 years, 40.0% women) with whole-brain cerebral blood flow (CBF) measured at […]
An UK randomized trial revealed that traditional dietary advice (TDA), low FODMAP diet (LFD) and gluten-free diet (GFD) are all effective approaches in non-constipated irritable bowel syndrome (IBS), but TDA is the most patient-friendly in terms of cost and convenience. A total of 99 patients with non-constipated IBS completed the […]
Two UK cohort studies among individuals with and without high blood pressure (HBP) found that the initiation of sodium-containing acetaminophen was associated with a significant higher risk of incident cardiovascular disease (CVD, including myocardial infarction, stroke, and heart failure) and all-cause mortality than non-sodium-containing acetaminophen. The studies used marginal structural […]
An US cohort study of religious sisters showed that many of them with mild cognitive impairment (MCI) never developed dementia, even reverted to normal cognition (NC) or experienced improvement without intervention. The study included 619 participants aged 75+ years, 472 were observed to have MCI at some point during the […]
A Canadian study demonstrated that preactivating lower body muscle (PREACT) and leg crossing with muscle tensing (TENSE) after standing attenuates symptoms and blood pressure (BP) drop of initial orthostatic hypotension (IOH) upon standing. The study included 24 female IOH participants (mean ± SD: 32 ± 8 years) completed 3 sit-to-stand […]
A double-blind, placebo-controlled, crossover trial concluded that regular daily intake of 4 g acetaminophen increases systolic blood pressure (BP) in individuals with hypertension by ≈5 mm Hg when compared with placebo. The trial randomized 110 patients of high BP to receive 1 g acetaminophen 4× daily or matched placebo for 2 […]
A randomized, controlled, crossover trial in overweight insulin-resistant volunteers in the Netherlands suggested that in contrast to Dim day–Bright evening condition, Bright day–Dim evening condition mostly elicited favorable metabolic outcomes. The trial included 14 overweight 40–75 years male and female, insulin-resistant volunteers between July 2018 and November 2019. Participants were randomly […]
A prospective study in China revealed that certain genotypes of alcohol metabolism might reduce or exacerbate the effects of alcohol on several cancers. Aldehyde dehydrogenase 2 (ALDH2)-rs671 G>A and alcohol dehydrogenase 1B (ADH1B)-rs1229984 G>A were genotyped in 150 722 adults, enrolled from 10 areas in China from 2004 to 2008. […]
A secondary analysis of a randomized blood pressure (BP) intervention trial suggested that certain BP medications could be used to prevent the development of cognitive decline. The analysis (April 2011 to July 2018) included 8685 patients of high BP 50 years or older with increased cardiovascular risk but without a […]