A prospective Danish cohort study revealed that subclinical obstructive coronary atherosclerosis is associated with a more than 8-fold elevated risk for myocardial infarction (MI). The study included 9533 asymptomatic persons aged 40 years or older without known ischemic heart disease. Coronary atherosclerosis was assessed with coronary computed tomography angiography and […]
A meta-analysis and a meta-regression of randomized clinical trials suggested that more intensive differential blood pressure (BP)–lowering may be beneficial for prevention of recurrent stroke and major cardiovascular events. The analysis included 10 randomized clinical trials comprising 40 710 patients (women 34%; mean age 65 years) with stroke or transient ischemic […]
A prospective UK birth cohort study demonstrate that marked changes in levels of risk factors and novel predictive biomarkers for cardiovascular diseases (CVD) occur from childhood to early adulthood. The data were from 7065 to 7626 offspring of a birth cohort study with repeat assessments of 148 molecular cardiometabolic traits […]
A collaborative analysis of 3 multinational trials suggested that inflammatory risk was a stronger predictor of cardiovascular disease (CVD) events, CVD death, and all-cause death than residual cholesterol risk in statin users. The analysis included 31245 statin users with/or at high risk of atherosclerotic disease. The observed ranges for baseline […]
A French prospective cohort study concluded that better cardiovascular health (CVH) and the maintenance or improvement of CVH were associated with a lower risk of cancer. The study population included 13,933 participants (mainly Caucasian, mean age 45.3 years, 24% women). After a median follow-up of 24.8 years (19.4-24.9 years), 2,010 […]
A US cross sectional and observational cohort study indicated that sleep irregularity was associated with several markers of subclinical atherosclerosis. The study included 2032 participants (mean age, 68.6±9.2 years; White 37.9%, Chinese 11.1%, Black 27.6%, Hispanic 23.4%) underwent assessments of coronary artery calcium, carotid plaque presence, carotid intima‐media thickness, and the […]
A prospective UK cohort study suggested that higher free sugar intake was associated with higher cardiovascular disease (CVD) incidence and higher triglyceride concentrations within all lipoproteins. Higher fiber intake and replacement of refined grain starch and free sugars with wholegrain starch and non-free sugars, respectively, may be protective for incident […]
Three trials have shown remarkable benefits of thrombectomy in patients with large ischemic strokes in countries with different medical systems. The benefits of thrombectomy were consistent across age, degree of neurologic deficit, imaging characteristics, time of treatment, and geographic location. Thrombectomy resulted in significantly better functional outcomes than medical care […]
A Swedish population-wide longitudinal cohort study suggested that β-blockers were associated with reductions in violence. The study included 1,400,766 individuals aged 15 years or older (50 years and over 86.8%, women 52.2%) who had collected β-blocker prescriptions and followed them for 8 years between 2006 and 2013. 6.9% of the […]
A prospective US cohort study indicated that premature cardiovascular disease (CVD before 60 years) is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVD risk factors. The study included 3,146 participants, who were 18-30 years at baseline (1985-86, […]