A retrospective, new-user comparative cohort study revealed that angiotensin receptor blockers (ARBs) do not differ statistically significantly in effectiveness at the class level compared with ACE (angiotensin-converting enzyme) inhibitors as first-line treatment for high blood pressure but present a better safety profile. The study included all patients with high blood […]
A scientific statement from the American Heart Association has been released for the diagnosis and management of myocarditis in children. Myocarditis remains a clinical challenge in pediatrics. Originally, it was recognized at autopsy before the application of endomyocardial biopsy, which led to a histopathology-based diagnosis. Given the invasive and low-sensitivity […]
Dr. Markowitz at Columbia University outlined the types of therapies that are proven to work for people with a major trauma. The most common diagnosis and response to trauma is depression. A lot of other people are going to develop post-traumatic stress disorder (PTSD). Other people will develop substance abuse. […]
The International Association for the Study of Pain has proposed a new term, nociplastic pain, to describe a third category of pain that is mechanistically distinct from nociceptive pain, which is caused by ongoing inflammation and damage of tissues, and neuropathic pain, which is caused by nerve damage. The mechanisms […]
A UK single-arm dietary intervention study suggests that postprandial inflammation is largely driven by acute elevations in circulating triglyceride (TG). Glycoprotein acetylation (GlycA) after mixed meals may be a promising candidate biomarker for assessing the food-induced inflammatory response within typical dietary habits. The study included 1002 healthy adults aged 18–65 […]
A novel microRNA has been identified in mice and humans with myocarditis, and that the human homologue could be used to distinguish patients with myocarditis from those with myocardial infarction. The human homologue, designated hsa-miR-Chr8:96, was identified in four independent cohorts of patients with myocarditis. The area under the receiver-operating-characteristic […]
The 2021 secondary stroke prevention guideline from the American Heart Association/American Stroke Association: 1. Recommendations for the diagnostic workup to define ischemic stroke etiology. 2. Management of vascular risk factors remains extremely important, including (but not limited to) diabetes, smoking cessation, lipids, and especially hypertension. 3. Lifestyle factors: Low-salt and […]
Both a scientific statement from the American Heart Association and an individual participant-level data meta-analysis support that pharmacological blood pressure (BP) lowering is effective for primary and secondary prevention of major cardiovascular disease (CVD), even at BP levels currently not considered for treatment. The statement provides evidence suggesting that in […]
A prospective UK cohort study revealed that younger age at diabetes onset was associated with higher risk of subsequent dementia. The study included 10 095 participants (67.3% men; aged 35-55 years in 1985-1988), with a total of 1710 cases of diabetes and 639 cases of dementia recorded over a median follow-up […]
A Canadian population-based cohort study revealed dose-dependent increases in skin cancer risk associated with thiazides in people aged 66 years and older. The study included a total of 302 634 adults aged ≥ 66 years prescribed an antihypertensive medication and 605 268 matched unexposed adults. Increasing thiazide exposure was associated […]