The secondary analysis of a US randomized, double-blind, placebo-controlled clinical trial suggested that vitamin D3 apparently reduced the risk of developing advanced cancer among adults who have normal but not elevated body mass index (BMI). The trial included 25 871 randomized participants (51% female; mean age, 67.1 years), 1617 were diagnosed […]
A randomized, double-blind, placebo-controlled trial in chronic kidney disease (CKD) and type 2 diabetes (T2D) concluded that treatment with finerenone reduced risks of CKD progression and cardiovascular (CV) events. Between September 2015 and June 2018, 5734 patients with CKD and T2D were randomly assigned in a 1:1 ratio to receive […]
A post-hoc analysis of a subset of adult participants in a randomized trial showed that changes in pancreas volume and shape occurred during 2 years of remission of type 2 diabetes (T2D) with weight management intervention. The analysis included 90 T2D participants randomly assigned to a weight management intervention (n=64) […]
A meta-analyses and Mendelian randomization study identified causal risk factors for type 2 diabetes (T2D). The study found evidence of causal associations between 34 exposures (19 risk factors and 15 protective factors) and T2D. Insomnia was identified as a novel risk factor (OR 1.17). The other 18 risk factors were […]
A meta-analysis suggested that long naps (more than 60 mins) were associated with a 30% greater risk of all-cause death and 34% higher likelihood of cardiovascular disease (CVD) compared to no napping. When night-time sleep was considered, long naps were linked with a higher risk of death only in those […]
The American Cancer Society just updated the guideline on diet and physical activity for cancer prevention, which is consistent with guidelines from the American Heart Association and the American Diabetes Association for the prevention of coronary heart disease and diabetes as well as for general health promotion. Recommendations for individuals: […]
A US retrospective cohort study found no association between angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARB) use and COVID-19 test positivity. The study included 18 472 patients tested for COVID-19 (mean age 49 years, 40% male, and 69% white), 12.4% were taking either ACEIs or ARBs. A positive […]
A retrospective cohort study in the US suggested that myocardial injury was prevalent among patients hospitalized with COVID-19, and was associated with higher risk of mortality. The study included 2736 patients (median age 66.4 years, 59.6% men) with COVID-19 admitted between February 27th and April 12th, 2020 with troponin-I (normal […]
International cohort studies suggest that adding azithromycin to hydroxychloroquine (HCQ) treatment may increase heart failure and cardiovascular mortality, potentially due to synergistic effects on QT length of ECG. Severe adverse events associated with HCQ-azithromycin were compared to HCQ-amoxicillin in rheumatoid arthritis patients aged 18+ and followed up over 30 days. […]
A nationwide Swedish cohort study suggests that in patients with chronic viral hepatitis, low-dose (75 mg or 160 mg) aspirin use was associated with a duration-dependent significantly lower risk of incident hepatocellular carcinoma and liver-related death than no use of aspirin, without a significantly higher risk of gastrointestinal bleeding. The […]