A population based cohort study in the UK showed that the use of angiotensin converting enzyme inhibitors (ACEIs) was associated with an increased risk of lung cancer. The association was particularly elevated among people using ACEIs for more than five years. The cohort of 992 061 patients newly treated with antihypertensive […]
Two prospective cohort studies showed that regular use of low-dose aspirin was associated with a reduced risk of ovarian cancer and that regular, long-term aspirin use was associated with a dose-dependent reduction in the risk of hepatocellular cancer (HCC). The first study in 2 cohorts of 93,664 (mean age 45.9 […]
A small randomized, double-blind, placebo-controlled trial in the US showed that oral dietary glutamine supplements effective and safe in patients with diarrhea-predominant irritable bowel syndrome (IBS-D) with intestinal hyperpermeability following an enteric infection. Participants (mean age 31.7, approximately 70% women, and 80% white) were randomized to glutamine (5 g/t.i.d.) or placebo […]
A prospective US cohort study and meta-analysis suggested that both high and low percentages of carbohydrate diets were associated with increased mortality, with minimal risk observed at 50–55% carbohydrate intake. The association was modified by the source of food, with higher mortality when carbohydrates were exchanged for animal-derived fat or […]
Canadian professional groups recommended deprescribing proton pump inhibitors (PPIs) in adults who have completed a minimum of 4 weeks of PPI treatment for heartburn or mild to moderate gastroesophageal reflux disease or esophagitis, and whose symptoms are resolved. Deprescirbing by decreasing the daily dose or stopping and changing to on-demand […]
A French prospective population-based cohort study suggests that healthy diet by following dietary recommendations could significantly contribute to cancer prevention. The study investigated the associations between several nutritional scores and overall, breast, prostate, and colorectal cancer risk in a large prospective population-based cohort. The study included 41,543 participants aged ≥40 […]
A randomized noninferiority trial in Australia suggested that intermittent energy restriction is an effective alternative diet strategy for the reduction of hemoglobin A1c (HbA1c) level comparable to continuous energy restriction in patients with type 2 diabetes (T2D), and it may be superior to continuous energy restriction for weight loss. The […]
A pooled analysis of individual patient data suggested that low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and higher doses of aspirin were only effective in patients weighing 70 kg or more. The analysis included 117 279 participants in […]
A Dutch population-based study revealed that a better diet quality is associated with larger brain tissue volumes. The study included 4,447 participants (average age 65.7; female 56.8%) underwent dietary assessment and brain MRI scanning between 2005 and 2015, excluding participants with an implausible energy intake, prevalent dementia, or cortical infarcts. […]
A study in US adults concluded that a healthy lifestyle could substantially reduce premature mortality and prolong life expectancy. The study included 123,329 adults and defined 5 low-risk lifestyle factors as never smoking, body mass index of 18.5 to 24.9 kg/m2, ≥30 min/d of moderate to vigorous physical activity, moderate […]