A Mendelian randomization (MR) study suggests a protective effect of morning preference on breast cancer risk add to other evidence of decreased risk of schizophrenia and depression. The study included 156 848 women in the multivariable regression and one sample MR analysis (7784 with a breast cancer diagnosis) and 122 977 breast […]
Two prospective cohort studies in the US concluded that increases in red meat consumption, especially processed meat, were associated with a higher risk of death; decreases in red meat consumption and simultaneous increases in healthy alternative food choices over time were associated with a lower mortality risk. The studies included […]
A longer period of follow up revealed that there was no evidence of a legacy effect or a mortality benefit with intensive glucose control, although participants with type 2 diabetes who had been randomly assigned to intensive glucose control for 5.6 years had a lower risk of cardiovascular events than […]
A cross-sectional, prospective cohort study in Germany suggests that low serum cholesterol levels in patients with type 2 diabetes (T2D) is associated with diabetic polyneuropathy (DPN). The study included 100 T2D patients (mean age 64.6 years; 68 male) from June 1, 2015, to March 31, 2018. Quantification of the nerve’s […]
An international panel issues a strong recommendation against thyroid hormones in adults with subclinical hypothyroidism (SCH, elevated TSH levels and normal free T4 levels). It does not apply to women who are trying to become pregnant or patients with TSH >20 mIU/L. It may not apply to patients with severe […]
A 52-week, randomized, open-label, controlled trial revealed that budesonide–formoterol used as needed was superior to albuterol used as needed and on par with budesonide maintenance for the prevention of asthma exacerbations. A total of 675 patients were randomly assigned to the albuterol (100 μg as needed for asthma symptoms) group; […]
A US randomized, controlled clinical trial revealed that a dietary change with increased vegetable, fruit, and grain intake reduced the risk of death from breast cancer in postmenopausal women. A total of 48,835 postmenopausal women, aged 50-79 years, with no previous breast cancer and dietary fat intake ≥32% of total […]
A personalized predictive model that takes into consideration unique features of an individual in addition to food characteristics was more predictive than current dietary approaches for glycemic responses to food consumed. The study enrolled 327 individuals without diabetes from October 11, 2016, to December 13, 2017 in the US. The […]
A series of systematic reviews and meta-analyses of prospective studies and randomized controlled trials with relatively high intakes of dietary fiber and whole grains revealed complementary findings, and striking dose-response evidence indicates that the relationships to several non-communicable diseases could be causal. The analyses included about 135 million person-years of […]
A US study suggested that genetic variations may be at play with vitamin E, increasing cancer risk in some individuals while decreasing risk for others. Multiple pathways may link the enzyme catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer. The most extensively studied variant in COMT comes in […]