A systematic review and network meta-analysis provided the most comprehensive data synthesis on pharmacological treatments for adults with insomnia. The study included 170 trials (36 interventions and 47 950 participants) in the systematic review and 154 double-blind, randomized controlled trials (30 interventions and 44 089 participants) for the network meta-analysis. Benzodiazepines, doxylamine, […]
A UK cohort study and Mendelian randomization (MR) suggested that moderate alcohol consumption [>7 units (56 g) alcohol weekly] was associated with markers of higher brain iron and worse cognitive function. The study included 20,729 UK Biobank participants (mean age 54.8 years, 48.6% female). Multiorgan susceptibility-weighted magnetic resonance imaging (~9.60 […]
A study of incident dementia, midlife Life’s Simple 7 (LS7) scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer’s Disease showed that across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia in a US cohort. The study included 8,823 European […]
An observational comparative cohort study with secondary database analysis suggested that the real-world effect of using antidepressants did not continue to improve patients’ health-related quality of life (HRQoL) over time. The study was using data from a US nationally representative database. HRQoL was measured using the SF-12 health survey and […]
A US prospective cohort study showed that a healthy lifestyle was associated with a longer life expectancy, and a larger proportion of their remaining years without Alzheimer’s dementia (AD). The study included 2449 participants aged 65 years and older (mean 76 years, 63% women, African American>50%) from 1993 to 2009, […]
A US prospective, observational cohort study suggested that excessive daytime napping and dementia may possess a bidirectional relationship or share common pathophysiological mechanisms. The study examined the longitudinal change of daytime napping inferred objectively by actigraphy, and the association with incident Alzheimer’s dementia (AD) in 1401 participants (mean age 81.4 […]
An US cohort study of religious sisters showed that many of them with mild cognitive impairment (MCI) never developed dementia, even reverted to normal cognition (NC) or experienced improvement without intervention. The study included 619 participants aged 75+ years, 472 were observed to have MCI at some point during the […]
A secondary analysis of a randomized blood pressure (BP) intervention trial suggested that certain BP medications could be used to prevent the development of cognitive decline. The analysis (April 2011 to July 2018) included 8685 patients of high BP 50 years or older with increased cardiovascular risk but without a […]
A multi-domain lifestyle intervention among older Finnish adults was effective in preventing cerebrovascular events and total cardiovascular disease (CVD) events among those with a history of CVD. A total of 1259 individuals aged 60–77 years with elevated risk for dementia were randomized (1:1) to a 2-year multi-domain intervention with diet, […]
Guidance on how to stop antidepressants in a tolerable way has been produced by the Royal College of Psychiatrists. Prescriptions of antidepressants, primarily selective serotonin reuptake inhibitors and serotonin and norepinephrine reuptake inhibitors, has steadily increased over recent years. There is ongoing debate about their benefits and increasing recognition of […]