A UK pragmatic, superiority, open label, randomized controlled trial of sleep restriction therapy (SRT) versus sleep hygiene concluded that brief primary care nurse delivered SRT is both clinically effective and cost-effective in treating insomnia disorder and improving other aspects of mental health and functioning. A total of 642 participants (mean […]
A Swedish population-wide longitudinal cohort study suggested that β-blockers were associated with reductions in violence. The study included 1,400,766 individuals aged 15 years or older (50 years and over 86.8%, women 52.2%) who had collected β-blocker prescriptions and followed them for 8 years between 2006 and 2013. 6.9% of the […]
A prospective US cohort study indicated that premature cardiovascular disease (CVD before 60 years) is associated with worse midlife cognition and white matter health, which is not entirely driven by stroke/TIA and even independent of CVD risk factors. The study included 3,146 participants, who were 18-30 years at baseline (1985-86, […]
A comprehensive meta-analysis concluded that cognitive behavior therapy (CBT) is effective for depression across different formats, ages, target groups, and settings, and as effective as pharmacotherapies at the short term, but more effective at the longer term. The analysis included 409 trials (518 comparisons) with 52,702 patients. CBT had moderate […]
A prospective UK cohort study suggested that high levels of cognitively passive sedentary behaviors (SB) were associated with increased risk of dementia, while cognitively active SB were associated with reduced risk of dementia. The study included 146,651 participants who were 60 years or older (mean age 64.59 years) and did […]
A drug-target Mendelian randomization (MR) analysis indicated adverse neurocognitive effects related to statins but not proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition. Data were from a combined sample of ∼740,000 participants in predominantly European ancestry-based genome-wide association cohort studies. There was a neutral cognitive profile related to genetic PCSK9 inhibition, […]
The UK National Institute for Health and Care Excellence (NICE) has updated the guideline on management of depression with new recommendations. In the new guideline, depression is classified as “less severe” and “more severe”. More severe includes moderate and severe, and less severe includes mild and sub-threshold depression. Sub-threshold has […]
A systematic review and network meta-analysis provided the most comprehensive data synthesis on pharmacological treatments for adults with insomnia. The study included 170 trials (36 interventions and 47 950 participants) in the systematic review and 154 double-blind, randomized controlled trials (30 interventions and 44 089 participants) for the network meta-analysis. Benzodiazepines, doxylamine, […]
A UK cohort study and Mendelian randomization (MR) suggested that moderate alcohol consumption [>7 units (56 g) alcohol weekly] was associated with markers of higher brain iron and worse cognitive function. The study included 20,729 UK Biobank participants (mean age 54.8 years, 48.6% female). Multiorgan susceptibility-weighted magnetic resonance imaging (~9.60 […]
A study of incident dementia, midlife Life’s Simple 7 (LS7) scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer’s Disease showed that across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia in a US cohort. The study included 8,823 European […]