Findings from a prospective cohort study challenge current global dietary guidelines. A total of 135 335 individuals aged 35 to 70 years without cardiovascular disease (CVD) were enrolled between Jan 1, 2003, and March 31, 2013 from 613 communities in 18 low-income, middle-income, and high-income countries in seven geographical regions globally. […]
A randomized, double-blind trial of canakinumab targeting interleukin-1β innate immunity pathway revealed a significantly lower rate of recurrent cardiovascular events in patients of myocardial infarction (MI). The trial included 10,061 patients with previous MI and a high-sensitivity C-reactive protein （hsCRP） level of 2 mg or more per liter. Canakinumab (at […]
Patient-reported outcomes among participants who received intensive BP treatment were similar to those among participants who received standard treatment. A total of 9361 participants with hypertension at high risk for cardiovascular disease were randomly assigned to a systolic blood-pressure (SBP) target of less than 120 mm Hg or 140 mm […]
A prospective cohort study of a general Japanese population demonstrated a significant independent association between increased day-to-day blood pressure variability (BPV) measured with home blood pressure monitoring and risk of dementia. The study included 1674 community-dwelling Japanese elderly without dementia, ≥60 years of age, and followed up for 5 years […]
A study revealed that estimated sodium intake (ESI) >3.7 g/day is associated with adverse cardiac remodeling and function. The study performed speckle-tracking analysis on echocardiograms with available urinary sodium data (N = 2,996). Mean age of participants was 49 ± 14 years, 57% were female, 50% were African American, and […]
A mendelian randomization study concluded that a genetic predisposition to higher serum calcium levels was associated with increased risk of coronary artery disease (CAD) and myocardial infarction (MI). The study included 60 801 CAD cases (approximately 70% with MI) and 123 504 noncases, with baseline data collected from 1948 and populations derived […]
A US study showed that improved diet quality over 12 years was consistently associated with a decreased risk of death. The study used Cox proportional-hazards models to calculate adjusted hazard ratios for total and cause-specific mortality among 47,994 women and 25,745 men from 1998 through 2010, with changes in diet […]
http://jamanetwork.com/The cross-sectional baseline data from a population-based cohort study in UK identified associations between body mass index (BMI) and risk of hypertension, coronary heart disease, type 2 diabetes, and elevated systolic and diastolic blood pressures. The study included 119 859 participants with complete phenotypic (medical and sociodemographic) and genetic data between […]
A UK prospective population-based study of long-term antiplatelet treatment (predominantly daily aspirin 75 mg enteric coated) in secondary prevention of vascular disease showed that the severity, case fatality, and poor functional outcome of bleeds increased with age, and that in patients aged 75 years or older, most major upper gastrointestinal […]
A US cohort study suggested that maternal use of lithium during the first trimester was associated with an increased risk of cardiac malformations, including Ebstein’s anomaly (right ventricular outflow tract obstruction defects). The study included 1,325,563 pregnancies in women who delivered a live-born infant between 2000 and 2010. Cardiac malformations […]