A systematic review and network meta-analysis, which allowed the simultaneous comparison of multiple achieved systolic blood pressure (SBP) levels on clinical outcomes while preserving trial-level treatment randomization, indicates that treating patients to reduce SBP below currently recommended targets may significantly reduce risk of cardiovascular disease (CVD) and all-cause mortality, with […]
A multigenerational, prospective cohort study in the US concluded that early onset (age <55 years) compared with late onset hypertension was associated with greater odds of cardiovascular death and with greater risk for hypertension in offspring. The study included 3614 first generation participants with mortality data and 1635 initially non-hypertensive […]
Systematic review followed by an individual patient data meta-analysis concluded that all non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, were found to be associated with an increased risk of acute myocardial infarction (AMI). Risk of AMI with celecoxib was comparable to that of traditional NSAIDS and was lower than for rofecoxib. […]
The American Academy of Neurology issued practice guideline to reduce brain injury following cardiopulmonary resuscitation. The guideline was developed after reviewing relevant published literature from 1966 to August 29, 2016. For patients who are comatose in whom the initial cardiac rhythm is either pulseless ventricular tachycardia (VT) or ventricular fibrillation […]