A Mendelian randomization (MR) study provided the evidence that the relationship between blood pressure (BP) and risk of atrial fibrillation (AF) might be causal. Genetic variants associated with the BP traits were retrieved from 299 024 subjects of European ancestry. Two-sample MR analyses were used to examine the potential causal association […]
A scientific statement from the American Heart Association revealed that there are good data showing clear associations between psychological health and cardiovascular disease (CVD) and risk, so called the mind-heart-body connection; there is increasing evidence that psychological health may be causally linked to biological, behavioral and psychosocial mechanisms that contribute […]
A Spanish observational study suggests that, although physical activity (PA) mitigates partly the detrimental effects of overweight/obesity on the risk of cardiovascular diseases (CVD), excess body weight per se is associated with a remarkable increase in the prevalence of major risk factors. The data from 527 662 participants [32% female; mean […]
An update of the previous 2018 systematic review and meta-analysis of vitamin and mineral supplementation on cardiovascular disease (CVD) outcomes and all-cause mortality shows similar findings for preventive benefits from both folic acid and B vitamins for stroke, and an increased risk with niacin (with statin) for all-cause mortality. In […]
A European cohort study revealed that even modest habitual alcohol intake of 1.2 drinks/day was associated with an increased risk of atrial fibrillation (AF). The study followed 107 845 individuals (median age 47.8 years, 48.3% men) from five community-based cohorts across Europe. The median alcohol consumption was 3 g/day. During median […]
A meta-analysis of randomized controlled trials concluded that colchicine treatment may reduce the risk of cardiovascular events in patients with coronary artery disease (CAD). The analysis included 5 randomized controlled trials with follow-up duration ≥6 months, comprising a total of 11,790 patients with CAD. Compared with placebo or no treatment, […]
A US cohort study suggested that in the absence of evidence of end-organ damage, conservative management of inpatient high blood pressure (BP) was associated with improved outcomes compared with more intensive management. The study included 22 834 adults hospitalized for noncardiovascular diagnoses from January 1 to December 31, 2017 (mean age, […]
Ten metabolites from seven prospective cohort studies were found to be associated with risk of stroke. The studies included 1,791 incident stroke events among 38,797 participants. Independent of traditional risk factors including hypertension, diabetes, smoking, and body mass index, amino acid histidine (hazard ratio [HR] per standard deviation [SD] = […]
Two studies suggest that low-density lipoprotein cholesterol (LDL-C) may not to be the main lipid contributor to atherosclerotic cardiovascular disease (ASCVD). The study in Spain included 6901 subjects in the high-risk primary prevention trial population (mean age: 67 years; body mass index: 30 kg/m2; 43% men; 48% with diabetes) with […]
A randomized, double-blind, placebo-controlled trial in chronic kidney disease (CKD) and type 2 diabetes (T2D) concluded that treatment with finerenone reduced risks of CKD progression and cardiovascular (CV) events. Between September 2015 and June 2018, 5734 patients with CKD and T2D were randomly assigned in a 1:1 ratio to receive […]