A secondary analysis of a randomized blood pressure (BP) intervention trial suggested that certain BP medications could be used to prevent the development of cognitive decline. The analysis (April 2011 to July 2018) included 8685 patients of high BP 50 years or older with increased cardiovascular risk but without a […]
A multi-domain lifestyle intervention among older Finnish adults was effective in preventing cerebrovascular events and total cardiovascular disease (CVD) events among those with a history of CVD. A total of 1259 individuals aged 60–77 years with elevated risk for dementia were randomized (1:1) to a 2-year multi-domain intervention with diet, […]
A Swedish population-based cohort study suggested that higher resting heart rate (RHR) was associated with increased risk for dementia and faster cognitive decline independent of cardiovascular disease (CVD) in a general population of elderly people. The study included 2147 participants (age≥60) who were free of dementia and regularly followed from […]
A retrospective cohort study concluded that high-grade exercise-induced premature ventricular contractions (PVCs) occurring during recovery were associated with long-term risk of cardiovascular mortality in asymptomatic individuals, but not PVCs occurring only during exercise. The study included a total of 5,486 asymptomatic individuals with a mean age of 45.4 years and […]
Higher sodium and lower potassium intakes, as measured in multiple 24-hour urine samples, were associated in a dose–response manner with a higher cardiovascular risk in a pooled random-effects meta-analysis of individual-participant data from six prospective cohorts of generally healthy adults in the US. The analysis included 10,709 participants, mean age […]
Pooled analysis of 2 US prospective cohort studies of patients with stable coronary heart disease (CHD) suggested that myocardial ischemia with mental stress, compared with no ischemia with mental stress, was significantly associated with an increased risk of cardiovascular (CV) death or nonfatal myocardial infarction (MI). The analysis included 918 […]
A Danish cohort study showed that the diagnostic value of a coronary artery calcium (CAC) score was age dependent, with smaller added diagnostic value for younger patients. The cohort included 23 759 symptomatic adult patients who underwent computed tomography angiography between January 2008 and December 2017; median age 58, 55% […]
A German longitudinal study suggested that the association between systolic blood pressure (SBP) and all-cause mortality in older adults may be modified by frailty, with a tendency toward lower risk among those with SBP≥130 mm Hg in frail older adults. The study included 1170 participants (median age 73.9 years, 41.6% […]
A longitudinal cohort study in Italy suggested that non-dipping and reverse dipping blood pressure (BP) patterns are associated with an increased prevalence of cardiac autonomic neuropathy and reduced survival. The study recruited 349 diabetic patients (52% women, age 57.1±11.9 y, BMI 29.4±5.9 kg/m2, HbA1c 8.6±2.1%, 284 with type 2 diabetes) […]
A pooled US cohorts study suggests that maintaining an optimal level of low-density lipoprotein cholesterol (LDL-C) throughout young adulthood and middle age can minimize the lifetime risk for atherosclerotic cardiovascular disease (CVD). The study included data of 18 288 participants (mean age 56.4, 56.4% women) collected from 1971 to 2017 from […]