An individual participant data meta-analysis concluded that most (>90%) of all reports of muscle symptoms with statin therapy were not due to the statin, although statins did cause a small proportional increase in reports of muscle pain, largely during the first year of treatment. The analysis included 19 double-blind trials […]
A multicenter, open-label, blinded–end point, randomized clinical trial in China showed that remote ischemic conditioning (RIC) was associated with better neurologic function in patients with acute moderate ischemic stroke. The trial randomly assigned 1893 patients (mean age, 65 years; women 34.1%; 93.8% completed the trial) within 48 hours after symptom […]
A meta-analyses and metaregressions concluded that the beneficial effects of salt substitutes on blood pressure and clinical outcomes were consistent and might be generalizable across diverse population subgroups worldwide. The study included 21 trials and 31 949 participants, with 19 reporting effects on blood pressure and 5 reporting effects on […]
Data from a validated and complete registration of all 2,494 acute myocardial infarction (MI) cases in Augsburg, Germany, during warm seasons (May to September) from 2001 to 2014, suggested that heat-related non-fatal MI risk was elevated among users of anti-platelet medication and beta-receptor blockers, respectively, but not among non-users, with […]
The American Heart Association has updated a construct of cardiovascular health (CVH), Life’s Essential 8, including diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure. Each metric has a new scoring algorithm ranging from 0 to 100 points, allowing generation of a […]
A dose‐response meta‐analysis suggested that the optimal combined intake of omega‐3 fatty acids for blood pressure (BP) lowering is likely between 2 g/d and 3 g/d. Doses above 3 g/d may be associated with additional benefits in lowering BP among high risk groups for cardiovascular diseases. The analysis included 71 randomized controlled trials […]
A US cohort study suggested that more active time, especially at moderate intensities, and less sedentary time, particularly in longer bouts, may reduce the risk of stroke. The study included 7607 participants (mean age 63.4 years; 54.5% female, 31.6% Black, and 68.4% White), including 54.7% of them resided in the […]
A prospective, multicenter biobank cohort study in the UK and US revealed that very high high-density lipoprotein cholesterol (HDL-C) levels were associated with higher mortality risk in patients with coronary artery disease (CAD). There were 14 478 UK participants (from 2006; mean age 62.1 years, 76.2% men) and 5467 US participants […]
A study of incident dementia, midlife Life’s Simple 7 (LS7) scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer’s Disease showed that across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia in a US cohort. The study included 8,823 European […]
A genetic association study indicates that 0.7% of participants harbor a pathogenic variant related to inherited cardiomyopathy and are at increased risk of cardiovascular disease (CVD) and all-cause mortality. The study included 9667 US participants (mean age 54.0 years; 43.8% women; 27.5% African and 72.5% European ancestry) and 49 744 UK […]