A dose‐response meta‐analysis suggested that the optimal combined intake of omega‐3 fatty acids for blood pressure (BP) lowering is likely between 2 g/d and 3 g/d. Doses above 3 g/d may be associated with additional benefits in lowering BP among high risk groups for cardiovascular diseases. The analysis included 71 randomized controlled trials […]
A US cohort study suggested that more active time, especially at moderate intensities, and less sedentary time, particularly in longer bouts, may reduce the risk of stroke. The study included 7607 participants (mean age 63.4 years; 54.5% female, 31.6% Black, and 68.4% White), including 54.7% of them resided in the […]
A prospective, multicenter biobank cohort study in the UK and US revealed that very high high-density lipoprotein cholesterol (HDL-C) levels were associated with higher mortality risk in patients with coronary artery disease (CAD). There were 14 478 UK participants (from 2006; mean age 62.1 years, 76.2% men) and 5467 US participants […]
A study of incident dementia, midlife Life’s Simple 7 (LS7) scores and generated genetic risk scores (GRS) using genome-wide summary statistics of Alzheimer’s Disease showed that across strata of GRS, higher midlife LS7 scores were associated with lower risk of dementia in a US cohort. The study included 8,823 European […]
A genetic association study indicates that 0.7% of participants harbor a pathogenic variant related to inherited cardiomyopathy and are at increased risk of cardiovascular disease (CVD) and all-cause mortality. The study included 9667 US participants (mean age 54.0 years; 43.8% women; 27.5% African and 72.5% European ancestry) and 49 744 UK […]
The US Preventive Services Task Force recommends against initiating low-dose aspirin use for the primary prevention of cardiovascular disease (CVD) in adults 60 years or older. The decision to initiate low-dose aspirin use for the primary prevention of CVD in adults aged 40 to 59 years who have a 10% […]
A systematic review and meta-analysis concluded that sodium–glucose cotransporter-2 (SGLT2) inhibitors reduced hospitalizations for heart failure (HF) regardless of the presence of diabetes. The analysis included trials that randomly assigned adults with HF to SGLT2 inhibitors or control. Time-to-event individual patient data were reconstructed from published Kaplan–Meier plots; time-varying risk […]
A US open-label, multicenter, randomized trial concluded that in pregnant women with mild chronic high blood pressure (BP), a strategy of targeting BP<140/90 mm Hg was associated with better pregnancy outcomes than a strategy of reserving treatment only for severe high BP, with no increase in the risk of small-for-gestational-age […]
A systematic review and meta-analysis suggests that the absolute benefits of statins are modest and may not be strongly mediated through the degree of low-density lipoprotein cholesterol (LDL-C) reduction. The analysis included 21 randomized clinical trials that examined the effectiveness of statins in reducing total mortality and cardiovascular outcomes with […]
A substudy of the randomized clinical trial compared intensive vs standard systolic blood pressure (SBP) control revealed that the intensive BP treatment was associated with increased, rather than decreased, cerebral perfusion. The substudy included 547 participants (mean age 67.5 years, 40.0% women) with whole-brain cerebral blood flow (CBF) measured at […]