A prospective Chinese Mendelian randomization study revealed that participants with higher body mass index (BMI) but lower waist circumference (WC) had the lowest mortality risk among the oldest-old. The study enrolled 5306 community-based oldest-old (mean age 90.6 years) between 1998 and 2018. Genetic risk scores were constructed from 58 single-nucleotide […]
Data from a population-based cohort study in the Netherlands suggested that sarcopenic obesity (SO) may be associated with worse survival, and screening for muscle function may help for early identification and prevent premature death among older people. From March 1, 2009, to June 1, 2014, 5888 participants (mean age, 69.5 […]
The post hoc analysis of postintervention follow-up of calcium and vitamin D (CaD) supplements suggested reduced cancer mortality and increased cardiovascular disease (CVD) mortality. The multicenter trial across the US included 36 282 postmenopausal women randomized 1:1 to 1000 mg of calcium carbonate (400 mg of elemental calcium) with 400 IU […]
A prospective dose–response analysis of total daily steps with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels revealed that any number of daily steps above 2200 steps/day was associated with lower mortality and incident CVD risk, with 9000–10 500 steps/day being associated with the lowest mortality risk independent […]
A UK prospective cohort analysis suggested that both functional (subjective) and structural (objective) measures of social connection were independently associated with all-cause and cardiovascular disease (CVD) mortality. The analysis included 458,146 participants with a median of 12.6 years follow-up, 33,135 (7.2%) deaths, including 5112 (1.1%) CVD deaths. Friends/family visit frequencies < monthly were […]
A Spanish observational cohort study indicated that ambulatory blood pressure (BP), particularly night-time BP, was more informative about the risk of all-cause and cardiovascular death than clinic BP. The study used clinic and ambulatory BP data obtained from 59124 patients between March 1, 2004, to Dec 31, 2014. During a […]
A prospective US cohort study with up to 36 years of follow-up concluded that greater adherence to several healthy eating patterns was associated with a lower risk of total and cause-specific mortality. The study included 75 230 women (1984-2020, mean baseline age, 50.2 years) and 44 085 men (1986-2020, mean […]
A global study concluded that exposure to extreme hot and cold temperatures was associated with a higher mortality from multiple common cardiovascular diseases (CVD). The study used data of daily counts of specific CVD death from 567 cities in 27 countries across 5 continents in overlapping periods ranging from 1979 […]
An interim report of a US randomized trial in patients with stable coronary disease and moderate or severe ischemia concluded that there was no difference in all-cause mortality for an initial invasive strategy compared with an initial conservative strategy, with lower risk of cardiovascular mortality but higher risk of non-cardiovascular […]
The secondary analysis of a multicenter randomized clinical trial in the US and Puerto Rico showed that the beneficial effect of intensive treatment on cardiovascular and all-cause mortality did not persist after the trial, with increasing outpatient systolic blood pressure (SBP) levels in participants randomized to intensive treatment following the […]