A systematic review of 17 randomized trials involving 66,337 adults found that reducing or modifying saturated fat intake offers little or no clinically meaningful benefit over five years for people at low cardiovascular risk, but may lead to important reductions in mortality and major cardiovascular events among those at high […]
Adding carotid-artery stenting—but not carotid endarterectomy—to intensive medical management reduced the risk of stroke or death in patients with high-grade asymptomatic carotid stenosis. In two parallel, observer-blinded trials including more than 2,400 participants with ≥70% stenosis, the 4-year incidence of the primary composite outcome (any stroke or death from randomization […]
A study shows that eating a lot of highly processed foods is likely causing a significant number of early deaths around the world. First, a dose–response meta-analysis of observational cohort studies was performed to assess the association between ultraprocessed food consumption and all-cause mortality. Then, an estimation was made for […]
Two recent studies highlight the importance of physical activity volume and intensity in reducing cardiovascular disease (CVD) risk and improving longevity. The first study analyzed data from over 24,000 middle-aged and older non-exercisers in the UK Biobank, examining the effects of incidental physical activity (IPA)—unstructured daily movement outside formal exercise—on […]
A prospective US population-based cohort study suggested that higher intake of butter was associated with increased mortality, while higher intake of plant-based oils was associated with lower mortality. Substituting butter with plant-based oils may prevent premature deaths. There were 221 054 adults with mean age at baseline of 36.1 ~ 56.3 […]
A prespecified subgroup analysis of a Chinese randomized clinical trial suggested that salt substitution significantly reduced the risks of stroke recurrence and death. The analysis included 15 249 patients with stroke (mean age, 64.1 years; female 45.9%; male 54.1%) from an open-label, cluster randomized clinical trial. Patients were assigned to […]
A prospective cohort study suggests that personal exposure to brighter nights and darker days causes circadian disruption with poor health outcomes and increased mortality risk. Avoiding night light and seeking daylight may promote optimal health and longevity. From 2013 to 2016, 88,905 UK Biobank participants (mean age 62.4 years, 56.9% […]
A US prospective cohort study demonstrated that replacement of animal fat with an equivalent amount of plant fat, particularly fat from grains or vegetable oils, was associated with a lower mortality. The study enrolled 407 531 men and women (56.9% male; mean age 61.2 years) from 1995 to 1996 and followed […]
A US prospective study indicates that urinary metal levels are associated with increased mortality and cardiovascular disease (CVD) risk. The study included a racially diverse population of 6599 participants (mean age, 62.1 years; 53% female) with urinary metals available at baseline (2000 to 2001) and followed through December 2019. During […]
A Japanese nationwide cohort study suggested that a diverse array of electrocardiogram (ECG) abnormalities was associated with an increased mortality and cardiovascular disease (CVD). The study included data of 3 698 429 working individuals (mean age, 47.1 years; 66.6% male) from April 1, 2015, to March 31, 2022, 16.8% had 1 minor […]