A prospective cohort study suggests that personal exposure to brighter nights and darker days causes circadian disruption with poor health outcomes and increased mortality risk. Avoiding night light and seeking daylight may promote optimal health and longevity. From 2013 to 2016, 88,905 UK Biobank participants (mean age 62.4 years, 56.9% […]
A US prospective cohort study demonstrated that replacement of animal fat with an equivalent amount of plant fat, particularly fat from grains or vegetable oils, was associated with a lower mortality. The study enrolled 407 531 men and women (56.9% male; mean age 61.2 years) from 1995 to 1996 and followed […]
A US prospective study indicates that urinary metal levels are associated with increased mortality and cardiovascular disease (CVD) risk. The study included a racially diverse population of 6599 participants (mean age, 62.1 years; 53% female) with urinary metals available at baseline (2000 to 2001) and followed through December 2019. During […]
A Japanese nationwide cohort study suggested that a diverse array of electrocardiogram (ECG) abnormalities was associated with an increased mortality and cardiovascular disease (CVD). The study included data of 3 698 429 working individuals (mean age, 47.1 years; 66.6% male) from April 1, 2015, to March 31, 2022, 16.8% had 1 minor […]
A US cohort study concludes that there is no mortality benefit of multivitamin use. The study included 390 124 participants (median age, 61.5 years; 55.4% male) without major chronic diseases from 3 prospective cohort studies. 40.9% of participants were never smokers, and 40.3% were college educated. Among daily multivitamin users, 49.3% […]
A US prospective population based cohort study suggested that higher ultra-processed food intake was associated with slightly increased all-cause mortality. The associations were mainly driven by meat/poultry/seafood based ready-to-eat products, sugar and artificially sweetened beverages, dairy based desserts, and ultra-processed breakfast foods. The study included 74 563 women (1984-2018) and 39 501 […]
A prospective Chinese Mendelian randomization study revealed that participants with higher body mass index (BMI) but lower waist circumference (WC) had the lowest mortality risk among the oldest-old. The study enrolled 5306 community-based oldest-old (mean age 90.6 years) between 1998 and 2018. Genetic risk scores were constructed from 58 single-nucleotide […]
Data from a population-based cohort study in the Netherlands suggested that sarcopenic obesity (SO) may be associated with worse survival, and screening for muscle function may help for early identification and prevent premature death among older people. From March 1, 2009, to June 1, 2014, 5888 participants (mean age, 69.5 […]
The post hoc analysis of postintervention follow-up of calcium and vitamin D (CaD) supplements suggested reduced cancer mortality and increased cardiovascular disease (CVD) mortality. The multicenter trial across the US included 36 282 postmenopausal women randomized 1:1 to 1000 mg of calcium carbonate (400 mg of elemental calcium) with 400 IU […]
A prospective dose–response analysis of total daily steps with all-cause mortality and incident cardiovascular disease (CVD) by sedentary time levels revealed that any number of daily steps above 2200 steps/day was associated with lower mortality and incident CVD risk, with 9000–10 500 steps/day being associated with the lowest mortality risk independent […]