The analysis of genetic and lifestyle factors with cancer incidence in a general-population cohort suggested that genetic cancer risk may be reduced by adopting a healthy lifestyle. An incidence-weighted overall cancer polygenic risk score (CPRS) was constructed based on 20 cancer site-specific polygenic risk scores. Lifestyle was determined according to […]
A prospective study revealed that cardiovascular disease (CVD) risk factors, 10-year atherosclerotic CVD (ASCVD) risk score, and natriuretic peptide concentrations are associated with increased risk of future cancer. Conversely, a heart healthy lifestyle is associated with a lower risk of future cancer. The study included 20,305 participants, mean age 50 […]
The secondary analysis of a US randomized, double-blind, placebo-controlled clinical trial suggested that vitamin D3 apparently reduced the risk of developing advanced cancer among adults who have normal but not elevated body mass index (BMI). The trial included 25 871 randomized participants (51% female; mean age, 67.1 years), 1617 were diagnosed […]
A US study suggested that genetic variations may be at play with vitamin E, increasing cancer risk in some individuals while decreasing risk for others. Multiple pathways may link the enzyme catechol-O-methyltransferase (COMT) to the vitamin E supplement, alpha-tocopherol, and cancer. The most extensively studied variant in COMT comes in […]
A nationwide, randomized, placebo-controlled trial revealed that daily supplementation with high-dose vitamin D or n-3 fatty acids for 5 years among initially healthy adults in the US did not reduce the incidence of cancer or the incidence of major cardiovascular events. The trial included 25,871 participants (5106 black, ages >/=50 […]