A US randomized clinical trial of healthy adult identical twin pairs showed that a healthy plant-based diet offers a significant protective cardiometabolic advantage compared with a healthy omnivorous diet. The open-label, parallel, dietary randomized clinical trial enrolled 22 pairs of twins (N = 44, 34 female; mean age, 39.6 years; mean body […]
A Finnish randomized, infancy-onset cohort study indicated that accumulation of risk exposure to BP levels at all life stages contributed to adulthood carotid intima-media thickness (IMT). The study included 534 participants from July 1989 through January 2018 with annual BP (from age 7 months to 20 years), biennial IMT measurements […]
The US 2023 atrial fibrillation (AF) guideline emphasizes a rhythm control strategy and highlight the need for lifestyle and risk factor modification in addition to medical treatment. Key points including: The new proposed classification of AF by 4 stages, recognizes AF as a disease continuum that requires a variety of […]
A longitudinal cohort and mendelian randomization study suggested there was a modest, but significant longitudinal and causal relationship between neuroticism and atrial fibrillation (AF). In 394,834 UK participants (mean age 56.3 years, 45.9% male), AF occurred in 23,509 (6.0%) during a 10-year follow-up. Based on the median summary score from […]
A Spanish longitudinal cohort study suggested that the impact of low-density lipoprotein cholesterol (LDL-C) and systolic blood pressure (SBP) on subclinical atherosclerosis (SA) progression might be more pronounced in younger participants. SA was quantified as global plaque volume (bilateral carotid and femoral plaque burden) in 3,471 asymptomatic participants (baseline age […]
A UK prospective cohort analysis suggested that both functional (subjective) and structural (objective) measures of social connection were independently associated with all-cause and cardiovascular disease (CVD) mortality. The analysis included 458,146 participants with a median of 12.6 years follow-up, 33,135 (7.2%) deaths, including 5112 (1.1%) CVD deaths. Friends/family visit frequencies < monthly were […]
A multicenter, open-label, randomized crossover trial with blinded endpoint assessment in Europe revealed that 4 weeks of treatment with amlodipine, losartan, or atenolol resulted in differential effects on cerebrovascular reactivity (CVR) in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) but not in patients with symptomatic […]
A US randomized clinical trial found that time-restricted eating (TRE) without calorie counting was effective for weight loss and lowering of HbA1c levels in T2D adults. Between January 25, 2022, and April 1, 2023, 75 adults (mean age of 55, 71% women) with T2D were randomized to 1 of 3 […]
A US cohort study suggests that high blood pressure variability (BPV) can indicate increased incident dementia risk in older age. The study focused on 820 participants (mean age, 77.0 years; 58.0% females) with data of brain autopsy and midlife to late-life BP. A mean of 28.4 yearly SBP measurements were […]
A US cohort study suggested that metformin cessation was associated with increased dementia incidence. The cohort consisted of 12 220 early terminators and 29 126 routine users, respectively (women 46.2% and 46.6%, respectively; mean age at start of first metformin prescription 59.4 and 61.1 years, respectively). Early terminators had 1.21 times the […]