A Mendelian randomization study revealed that genetically predicted endogenous testosterone is positively linked to cardiovascular disease (CVD), including thromboembolism, heart failure (HF), and myocardial infarction (MI) in men. The study identified genetic predictors of endogenous testosterone from a genome wide association study of serum testosterone conducted in 3225 men of […]
A secondary analysis of data from a US randomized clinical trial suggests that smokers with high blood pressure (BP) may have a higher rate of cardiovascular events associated with intensive BP control. Of 9361 participants in the trial, 466 were current smokers with systolic BP > 144 mm Hg at […]
A new US National Academies report updated Dietary Reference Intakes for potassium (Adequate Intake [AI] 3400 mg for man and 2600 mg for most women per day) and sodium (AI 1500 mg/day, and Chronic Risk Reduction Intake 2300 mg/day) in healthy adults. There was insufficient evidence of risk of excess […]
A US prospective analysis revealed that higher consumption of nuts, especially tree nuts, is associated with lower cardiovascular disease (CVD) incidence and mortality in patients with diabetes. The analysis included 16,217 men (1986-2014) and women (1980-2014) with diabetes at baseline or diagnosed during follow-up. During 223,682 and 254,923 person-years of […]
A US retrospective longitudinal cohort study revealed that higher baseline push-up capacity is associated with a lower incidence of cardiovascular disease (CVD) events. The study was conducted between January 1, 2000, and December 31, 2010. There were 1562 participants underwent baseline examination, and 1104 with available push-up data included in […]
A US prospective multicenter longitudinal study suggested that higher intake of artificially sweetened beverages (ASB) was associated with increased risk of stroke, particularly small artery occlusion subtype, coronary heart disease, and all-cause mortality. The study included 81 714 postmenopausal women of ages 50 to 79 years at baseline who enrolled […]
A Japanese study suggested that vulnerable carotid plaque increases the risk of cortical cerebral microinfarcts (CMIs) and subsequent cognitive impairment. The study included 89 patients with >30% carotid stenosis on ultrasound. CMIs were identified in 26 patients (29%). Adjusted for age and sex, CMIs were associated with intraplaque hemorrhage, lacunar […]
A personalized predictive model that takes into consideration unique features of an individual in addition to food characteristics was more predictive than current dietary approaches for glycemic responses to food consumed. The study enrolled 327 individuals without diabetes from October 11, 2016, to December 13, 2017 in the US. The […]
A meta-analysis of genome-wide association studies of depression identified 102 independent variants, 269 genes, and 15 genesets associated with depression, including both genes and gene pathways associated with synaptic structure and neurotransmission. The analysis included 807,553 individuals (246,363 cases and 561,190 controls). An enrichment analysis provided further evidence of the […]
A prospective cohort study revealed that frequent consumption of fried foods, especially fried chicken and fried fish/shellfish, was associated with a higher risk of all cause and cardiovascular mortality in women in the US. The study included 106 966 postmenopausal women aged 50-79 at study entry who were enrolled between September […]