Two observational cohort studies revealed that altered levels of hemoglobin and liver function markers were associated with Alzheimer disease (AD). The first study included 12,305 participants without dementia of the population-based Dutch cohort (mean age 64.6 years, 57.7% women). During a mean follow-up of 12.1 years, 1,520 individuals developed dementia, […]
A systematic review and meta-analysis of prospective observational studies suggested that plant-based dietary patterns were associated with lower risk of type 2 diabetes (T2D), even after adjustment for body mass index. The analysis included 9 studies, totaling 307 099 participants with 23 544 cases of incident T2D. A significant inverse association was […]
A US retrospective cohort study concluded that both systolic and diastolic hypertension contribute significantly to cardiovascular risk. The study included 1.3 million adults in a general outpatient population. The burdens of systolic and diastolic hypertension each independently predicted adverse outcomes. In survival models, a continuous burden of systolic hypertension (≥140 […]
A UK retrospective cohort study suggested that a favorable lifestyle was associated with a lower dementia risk among participants with high genetic risk. The study included a total of 196 383 individuals (mean 64.1 years; 52.7% women) from 2006 to 2010, and followed up for 1 545 433 person-years (median follow-up, 8.0 years). […]
A US phase 2, multicenter, randomized controlled trial revealed that 2 years of moderate calorie restriction significantly reduced multiple cardiometabolic risk factors in young, non-obese adults. From May, 2007, to Feb, 2010, the trial randomly assigned 218 participants (21–50 years, BMI 22·0–27·9 kg/m 2) to a 25% calorie restriction diet […]
A meta-analysis of recent randomized controlled trials and systematic reviews concluded that reduced salt intake, omega-3 long-chain polyunsaturated fatty acid (LC-PUFA) use, and folate supplementation could reduce risk for some cardiovascular diseases (CVD). Combined calcium plus vitamin D might increase risk for stroke. The analysis selected 9 systematic reviews and […]
A prospective Chinese cohort study suggested a significant association between lower low-density lipoprotein cholesterol (LDL-C) and higher risk of intracerebral hemorrhage (ICH) when LDL-C was <70 mg/dL. The study included 96,043 participants (mean age 51.3 years) who were free of stroke, myocardial infarction, and cancer at baseline (2006). There were […]
A Mendelian randomization (MR) study suggests a protective effect of morning preference on breast cancer risk add to other evidence of decreased risk of schizophrenia and depression. The study included 156 848 women in the multivariable regression and one sample MR analysis (7784 with a breast cancer diagnosis) and 122 977 breast […]
The Global Council on Brain Health (GCBH), an independent collaborative of scientists, health professionals, scholars and policy experts from around the world who are working in areas of brain health related to human cognition concluded that there is no convincing evidence to recommend dietary supplements for brain health in healthy […]
Two prospective cohort studies in the US concluded that increases in red meat consumption, especially processed meat, were associated with a higher risk of death; decreases in red meat consumption and simultaneous increases in healthy alternative food choices over time were associated with a lower mortality risk. The studies included […]