A prospective Chinese Mendelian randomization study revealed that participants with higher body mass index (BMI) but lower waist circumference (WC) had the lowest mortality risk among the oldest-old. The study enrolled 5306 community-based oldest-old (mean age 90.6 years) between 1998 and 2018. Genetic risk scores were constructed from 58 single-nucleotide […]
A US cohort study suggested that physical activity (PA) appears to reduce cardiovascular disease (CVD) risk in part by acting through the brain’s stress-related activity. The study included a total of 50,359 adults (median age 60 years; 40.1% male). Stress-related neural activity was measured as the ratio of resting amygdalar-to-cortical […]
A randomized, non-inferiority trial in Singapore showed that mandibular advancement device (MAD) was non-inferior to continuous positive airway pressure (CPAP) for reducing 24-hour mean arterial blood pressure (BP) in patients with high BP and obstructive sleep apnea (OSA). The trial randomized 220 participants with moderate-to-severe OSA (apnea–hypopnea index AHI ≥15 […]
A Swedish population-based study provided reference ranges of ambulatory heart rate (HR) in a middle-aged population and suggested that the wide range of interindividual differences in HR largely independent of common clinical risk factors for cardiovascular diseases. The study included 5809 atrial fibrillation-free individuals, aged 50–65 years, with a healthy […]
A time to notch in lead I longer than 75 milliseconds has been proposed as a new ECG criterion for left bundle branch block (LBBB). The derivation cohort was from a prospective study of patients undergoing electrophysiological study from March 2016 through November 2019 and a validation cohort was assembled […]