An observational comparative cohort study with secondary database analysis suggested that the real-world effect of using antidepressants did not continue to improve patients’ health-related quality of life (HRQoL) over time. The study was using data from a US nationally representative database. HRQoL was measured using the SF-12 health survey and […]
The US Preventive Services Task Force recommends against initiating low-dose aspirin use for the primary prevention of cardiovascular disease (CVD) in adults 60 years or older. The decision to initiate low-dose aspirin use for the primary prevention of CVD in adults aged 40 to 59 years who have a 10% […]
A US decision analytical model suggested that achieving recommended goals of glycated hemoglobin (HbA1c), systolic blood pressure (SBP), low-density lipoprotein cholesterol (LDL-C), and body mass index (BMI) may extend the life expectancy (LE) of people with type 2 diabetes (T2D). The model was calibrated to a nationally representative sample of […]
A US prospective cohort study showed that a healthy lifestyle was associated with a longer life expectancy, and a larger proportion of their remaining years without Alzheimer’s dementia (AD). The study included 2449 participants aged 65 years and older (mean 76 years, 63% women, African American>50%) from 1993 to 2009, […]
A systematic review and meta-analysis concluded that sodium–glucose cotransporter-2 (SGLT2) inhibitors reduced hospitalizations for heart failure (HF) regardless of the presence of diabetes. The analysis included trials that randomly assigned adults with HF to SGLT2 inhibitors or control. Time-to-event individual patient data were reconstructed from published Kaplan–Meier plots; time-varying risk […]
A US open-label, multicenter, randomized trial concluded that in pregnant women with mild chronic high blood pressure (BP), a strategy of targeting BP<140/90 mm Hg was associated with better pregnancy outcomes than a strategy of reserving treatment only for severe high BP, with no increase in the risk of small-for-gestational-age […]
A US randomized, controlled, crossover study in healthy, nonobese individuals revealed that sleep restriction combined with ad libitum food promotes excess energy intake, weight gain and particularly central accumulation of fat without changing energy expenditure. The study included 12 healthy, nonobese individuals (9 males, age range 19 to 39 years), […]