Two UK cohort studies among individuals with and without high blood pressure (HBP) found that the initiation of sodium-containing acetaminophen was associated with a significant higher risk of incident cardiovascular disease (CVD, including myocardial infarction, stroke, and heart failure) and all-cause mortality than non-sodium-containing acetaminophen. The studies used marginal structural […]
An US cohort study of religious sisters showed that many of them with mild cognitive impairment (MCI) never developed dementia, even reverted to normal cognition (NC) or experienced improvement without intervention. The study included 619 participants aged 75+ years, 472 were observed to have MCI at some point during the […]
A Canadian study demonstrated that preactivating lower body muscle (PREACT) and leg crossing with muscle tensing (TENSE) after standing attenuates symptoms and blood pressure (BP) drop of initial orthostatic hypotension (IOH) upon standing. The study included 24 female IOH participants (mean ± SD: 32 ± 8 years) completed 3 sit-to-stand […]
A double-blind, placebo-controlled, crossover trial concluded that regular daily intake of 4 g acetaminophen increases systolic blood pressure (BP) in individuals with hypertension by ≈5 mm Hg when compared with placebo. The trial randomized 110 patients of high BP to receive 1 g acetaminophen 4× daily or matched placebo for 2 […]
A randomized, controlled, crossover trial in overweight insulin-resistant volunteers in the Netherlands suggested that in contrast to Dim day–Bright evening condition, Bright day–Dim evening condition mostly elicited favorable metabolic outcomes. The trial included 14 overweight 40–75 years male and female, insulin-resistant volunteers between July 2018 and November 2019. Participants were randomly […]
A prospective study in China revealed that certain genotypes of alcohol metabolism might reduce or exacerbate the effects of alcohol on several cancers. Aldehyde dehydrogenase 2 (ALDH2)-rs671 G>A and alcohol dehydrogenase 1B (ADH1B)-rs1229984 G>A were genotyped in 150 722 adults, enrolled from 10 areas in China from 2004 to 2008. […]