A U.S. Food and Drug Administration (FDA) review found that fluoroquinolone antibiotics can increase the occurrence of rare but serious events of ruptures or tears in the main artery of the body, so called aortic dissections or aneurysm. Systemic use given by mouth or through an injection of fluoroquinolones should […]
A network meta-analysis of 391 randomized controlled trials (RCTs) confirmed modest but consistent reductions in systolic blood pressure (SBP) in many studied exercise interventions across all populations but individuals receiving medications generally achieved greater reductions than those following structured exercise regimens. The analysis included 197 RCTs of exercise interventions (10 461 […]
An US randomized crossover study showed that chronic dietary red meat increases systemic trimethylamine N-oxide (TMAO) levels through enhanced dietary precursors, increased microbial trimethylamine (TMA)/TMAO production from carnitine, but not choline, and reduced renal TMAO excretion. Discontinuation of dietary red meat reduces plasma TMAO within 4 weeks. There were 113 healthy […]
A prospective global cohort study suggested that total sleep duration of 6–8 h per day is associated with the lowest risk of deaths and major cardiovascular events (MCEs). Daytime napping is associated with increased risks of MCEs and deaths in those with >6 h of nighttime sleep but not in those sleeping […]