A prospective, randomized, double-blind, double-dummy, placebo and celecoxib (200 mg/day)-controlled trial concluded that a 800 mg/day pharmaceutical-grade Chondroitin sulfate (CS) is superior to placebo and similar to celecoxib in reducing pain and improving function over 6 months in symptomatic knee osteoarthritis (OA) patients. The trial included 604 patients of knee osteoarthritis in […]
A multigenerational, prospective cohort study in the US concluded that early onset (age <55 years) compared with late onset hypertension was associated with greater odds of cardiovascular death and with greater risk for hypertension in offspring. The study included 3614 first generation participants with mortality data and 1635 initially non-hypertensive […]
Systematic review followed by an individual patient data meta-analysis concluded that all non-steroidal anti-inflammatory drugs (NSAIDs), including naproxen, were found to be associated with an increased risk of acute myocardial infarction (AMI). Risk of AMI with celecoxib was comparable to that of traditional NSAIDS and was lower than for rofecoxib. […]
A panel of experts made a strong recommendation against the use of arthroscopy in nearly all patients with degenerative knee disease, based on linked systematic reviews. The recommendation applies to patients with or without imaging evidence of osteoarthritis, mechanical symptoms, or sudden symptom onset. Degenerative knee disease is a chronic […]
A large US population based cohort study revealed that increased risks of all cause mortality and nine specific causes of death were associated with both processed and unprocessed red meat, accounted for, in part, by heme iron intake and nitrate/nitrite from processed meat. Replacing the intake of red meat with […]
The American Academy of Neurology issued practice guideline to reduce brain injury following cardiopulmonary resuscitation. The guideline was developed after reviewing relevant published literature from 1966 to August 29, 2016. For patients who are comatose in whom the initial cardiac rhythm is either pulseless ventricular tachycardia (VT) or ventricular fibrillation […]