Canadian professional groups recommended deprescribing proton pump inhibitors (PPIs) in adults who have completed a minimum of 4 weeks of PPI treatment for heartburn or mild to moderate gastroesophageal reflux disease or esophagitis, and whose symptoms are resolved. Deprescirbing by decreasing the daily dose or stopping and changing to on-demand […]
A French prospective population-based cohort study suggests that healthy diet by following dietary recommendations could significantly contribute to cancer prevention. The study investigated the associations between several nutritional scores and overall, breast, prostate, and colorectal cancer risk in a large prospective population-based cohort. The study included 41,543 participants aged ≥40 […]
A randomized noninferiority trial in Australia suggested that intermittent energy restriction is an effective alternative diet strategy for the reduction of hemoglobin A1c (HbA1c) level comparable to continuous energy restriction in patients with type 2 diabetes (T2D), and it may be superior to continuous energy restriction for weight loss. The […]
A pooled analysis of individual patient data suggested that low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and higher doses of aspirin were only effective in patients weighing 70 kg or more. The analysis included 117 279 participants in […]
A Dutch population-based study revealed that a better diet quality is associated with larger brain tissue volumes. The study included 4,447 participants (average age 65.7; female 56.8%) underwent dietary assessment and brain MRI scanning between 2005 and 2015, excluding participants with an implausible energy intake, prevalent dementia, or cortical infarcts. […]
A study in US adults concluded that a healthy lifestyle could substantially reduce premature mortality and prolong life expectancy. The study included 123,329 adults and defined 5 low-risk lifestyle factors as never smoking, body mass index of 18.5 to 24.9 kg/m2, ≥30 min/d of moderate to vigorous physical activity, moderate […]
The US Preventive Services Task Force has updated recommendations of exercise, but not vitamin D for fall prevention interventions in community-dwelling older adults. According to a systematically review of 62 randomized clinical trials (N = 35 058), multifactorial intervention trials were associated with a reduction in falls (incidence rate ratio [IRR], 0.79). Exercise […]
A Danish study suggests that weight loss from childhood to early adulthood can reduce the increased risks of type 2 diabetes (T2D) among overweight and obese boys. The study included 62,565 Danish men. Overweight was defined as body mass index ≥17.38 at age 7, ≥21.82 at age 13, and ≥25 […]
An international, multicenter, randomized trial concluded that the use of risk assessment with multiparametric magnetic resonance imaging (MRI) and MRI-targeted biopsy was superior to standard transrectal ultrasonography–guided biopsy for prostate-cancer detection in men with a raised prostate-specific antigen level who had not undergone biopsy. A total of 500 men underwent […]
A multi-center registry in the US revealed that myocarditis associated with immune checkpoint inhibitors (ICI) may occur early, has a malignant course and may respond to higher doses of steroids. The initial 35 cases were diagnosed between November 2013 and July 2017, with an incidence of 1.9% and median onset […]