Canadian professional groups recommended deprescribing proton pump inhibitors (PPIs) in adults who have completed a minimum of 4 weeks of PPI treatment for heartburn or mild to moderate gastroesophageal reflux disease or esophagitis, and whose symptoms are resolved. Deprescirbing by decreasing the daily dose or stopping and changing to on-demand (as needed) use of PPIs or considering histamine-2 receptor antagonist as an alternative to PPIs, after 4 weeks of treatment when symptoms have resolved. However, the recommendations do not apply to those who have or have had Barrett esophagus, severe esophagitis grade C or D, or documented history of bleeding gastrointestinal ulcers. There is growing concern about overuse of PPIs. Source: https://www.ti.ubc.ca/; http://www.cfp.ca/
