A multicenter, controlled, prospective endpoint trial confirmed that routinely taking blood pressure (BP)-lowering medications at bedtime, as opposed to upon waking, resulted in improved ambulatory BP control (significantly enhanced decrease in asleep BP and increased sleep-time relative BP decline, i.e. BP dipping) and markedly reduced major cardiovascular disease (CVD) events. […]
Data extracted from a primary prevention trial showed that aspirin significantly increases overall gastrointestinal (GI) bleeding risk in the elderly. The trial was conducted throughout 2010–2017 (n=19 114) in community-dwelling persons aged ≥70 years with low-dose enteric-coated aspirin or placebo. Over a median follow-up of 4.7 years (88 389 person years), there […]
An analysis with critically reviewing the clinical outcomes of randomized controlled trials (RCTs) of cholesterol reduction challenges the current approach to cardiovascular disease (CVD) prevention through targeted reductions of low density lipoprotein cholesterol (LDL-C). Drug treatment to reduce LDL-C to target levels (30% and 50% or more reduction for individuals […]
A US longitudinal observational cohort study suggests that APOE*2 allele and lower pulse pressure predicts resistance to amyloid-beta (Aβ) deposition in advanced aging. Of 100 participants, mean age at last cognitive evaluation was 92.0 years (range 86-100). Mean follow-up time from baseline to last measured Aβ status was 12.3 years […]
A US prospective observational cohort study revealed that higher plant protein intake was associated with reductions in risk of overall and cardiovascular disease (CVD) mortality. The study included 237 036 men (57%, median ages 62.2) and 179 068 women (median age 62.0). Based on 6 009 748 person-years of observation, 77 614 deaths (18.7%; 49 297 […]
A global analysis of pooled population-based studies showed the global repositioning of lipid-related risk over the past nearly four decades, with non-optimal cholesterol shifting from high-income countries in northwestern Europe, north America and Australasia to countries in east and southeast Asia and Oceania. The analysis included 1,127 population-based studies that measured […]
A US study of 3 prospective cohorts suggests that greater adherence to various healthy eating patterns was consistently associated with lower risk of cardiovascular disease (CVD). The final study sample included 74 930 women in the 1st cohort (mean baseline age, 50.2 years), 90 864 women in the 2nd cohort (mean baseline […]
A US cohort study revealed that beginning with a systolic blood pressure (SBP) level of 90 mm Hg, there was a stepwise increase in the prevalence of traditional atherosclerotic cardiovascular disease (ASCVD) risk factors, coronary artery calcium, and the risk of ASCVD. The study included 1457 participants free of ASCVD […]
A US comparative effectiveness study suggests that, given the up-front perioperative risks associated with carotid endarterectomy (CEA) and the reduced benefit derived from revascularization, initial medical therapy may be an acceptable treatment strategy for asymptomatic carotid stenosis. The study included 5221 patients who received carotid imaging between January 1, 2005, […]
A cohort study in Taiwan suggested that among patients with atrial fibrillation (AF) with prior ICH, non–vitamin K antagonist oral anticoagulants (NOACs) use was associated with lower rates of intracranial hemorrhage (ICH) and major bleeding compared with warfarin use, whereas the rate of ischemic stroke was similar. The study included […]