A longer period of follow up revealed that there was no evidence of a legacy effect or a mortality benefit with intensive glucose control, although participants with type 2 diabetes who had been randomly assigned to intensive glucose control for 5.6 years had a lower risk of cardiovascular events than […]
A prospective, controlled, electronic diary–based US study suggests that anger or stress can trigger atrial fibrillation (AF), but use of β-blockers is associated with greatly attenuated risk. The study included 91 patients (mean age 59) with a history of paroxysmal or persistent AF recorded their rhythm on event monitors at […]
A cross-sectional, prospective cohort study in Germany suggests that low serum cholesterol levels in patients with type 2 diabetes (T2D) is associated with diabetic polyneuropathy (DPN). The study included 100 T2D patients (mean age 64.6 years; 68 male) from June 1, 2015, to March 31, 2018. Quantification of the nerve’s […]
A UK prospective cohort study suggested that habitual use of glucosamine supplement to relieve osteoarthritis pain might also be related to lower risks of cardiovascular diseases (CVD) events. The study enrolled 466 039 participants from 2006 to 2010. During a median follow-up of 7 years, there were 10 204 incident CVD events, […]
The US FDA approved tafamidis meglumine (Vyndaqel) and tafamidis (Vyndamax) for the treatment of wild-type or hereditary transthyretin amyloid (ATTR) cardiomyopathy based on a trial that showed a significant reduction in mortality, cardiovascular hospitalizations, and in decline in functional capacity and quality of life. The multicenter, international, double-blind, placebo-controlled, phase […]
A longitudinal analysis in Australia revealed that sitting is associated with all-cause and cardiovascular disease (CVD) mortality risk among sedentary adults; moderate-to-vigorous physical activity (MVPA) doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations. During an 8.9-year (median) follow-up, a total of 8,689 deaths (1,644 due […]
A US prospective cohort study revealed that skipping breakfast was associated with a significantly increased risk of mortality from cardiovascular disease (CVD). The study included a nationally representative sample of 6,550 adults (mean age 53.2 years; 48.0% male) from 1988 to 1994, with 17 to 23 years of follow-up. In […]
A Chinese genetic epidemiological analyses revealed that alcohol intake uniformly increases blood pressure (BP) and stroke, indicating that the apparently protective effects of moderate alcohol intake against stroke suggested by conventional epidemiological analyses are largely non-causal. The study enrolled 512 715 adults between June 25, 2004, and July 15, 2008, from […]
An analysis of pooled individual participant data collected between March 25, 1985, and August 31, 2016 revealed that higher consumption of dietary cholesterol or eggs was significantly associated with higher risk of incident cardiovascular disease (CVD) and all-cause mortality in a dose-response manner. The analysis included 29 615 participants (mean age […]
A Mendelian randomization study revealed that genetically predicted endogenous testosterone is positively linked to cardiovascular disease (CVD), including thromboembolism, heart failure (HF), and myocardial infarction (MI) in men. The study identified genetic predictors of endogenous testosterone from a genome wide association study of serum testosterone conducted in 3225 men of […]